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Mouse Proteome Project - [Protein-Organelle-Database]
Titel: Mouse Proteome Project - [Protein-Organelle-Database]
Titel Kurzform: Mouse Proteome Project
Identifier: http://tap.med.utoronto.ca/~mts/
Autor: Ignatchenko, Alexandr; Chung, Clement
Zusammenfassung: Organs and organelles represent core biological systems in mammals, but the diversity in protein composition remains unclear. Here, we combine subcellular fractionation with exhaustive tandem mass spectrometry-based shotgun sequencing to examine the protein content of four major organellar compartments (cytosol, membranes [microsomes], mitochondria and nuclei) in six organs (brain, heart, kidney, liver, lung and placenta) of the laboratory mouse, Mus musculus. Using rigorous statistical filtering and machine-learning methods, the subcellular localization of 3274 of the 4768 proteins identified was determined with high-confidence, including 1503 previously uncharacterized factors, while tissue-selectivity was evaluated by comparison to previously reported mRNA expression patterns. This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal. [Information of the supplier]
Die Datenbank enthält Fakten: Vorkommen von Proteinen in Organellen / Organen. Sie ist kostenfrei verfügbar.
Thema: Proteine (572.6);
Mammalia (Säugetiere) (599)
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Zielgruppe: Fortgeschrittene; Experten
Sprache: Englisch
Format: Website; Datenbank
Ressourcentyp: Fakten-Datenbanken
Zugang: frei
Letzte Änderung des Metadatensatzes: 24.02.2009
Metadatenlieferant: UBFfm
URL dieses vifabio-Datensatzes: http://www.vifabio.de/iqfBio/detail/1614
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