Titel: | Mouse Proteome Project - [Protein-Organelle-Database] |
Titel Kurzform: | Mouse Proteome Project |
Identifier: | http://tap.med.utoronto.ca/~mts/ |
Autor: | Ignatchenko, Alexandr; Chung, Clement |
Zusammenfassung: |
Organs and organelles represent core biological systems in mammals, but the diversity in protein composition remains unclear. Here, we combine subcellular fractionation with exhaustive tandem mass spectrometry-based shotgun sequencing to examine the protein content of four major organellar compartments (cytosol, membranes [microsomes], mitochondria and nuclei) in six organs (brain, heart, kidney, liver, lung and placenta) of the laboratory mouse, Mus musculus. Using rigorous statistical filtering and machine-learning methods, the subcellular localization of 3274 of the 4768 proteins identified was determined with high-confidence, including 1503 previously uncharacterized factors, while tissue-selectivity was evaluated by comparison to previously reported mRNA expression patterns. This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal. [Information of the supplier] Die Datenbank enthält Fakten: Vorkommen von Proteinen in Organellen / Organen. Sie ist kostenfrei verfügbar. |
Thema: |
Proteine (572.6); Mammalia (Säugetiere) (599) » finde ähnliche Quellen! |
Zielgruppe: | Fortgeschrittene; Experten |
Sprache: | Englisch |
Format: | Website; Datenbank |
Ressourcentyp: | Fakten-Datenbanken |
Zugang: | frei |
Letzte Änderung des Metadatensatzes: | 24.02.2009 |
Metadatenlieferant: |
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URL dieses vifabio-Datensatzes: | http://www.vifabio.de/iqfBio/detail/1614 |
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