Our goal: to understand protein folding, misfolding, and related diseases. Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out these important functions, they assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, in many ways remains a mystery. Moreover, when proteins do not fold correctly (i.e. "misfold"), there can be serious consequences, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, Huntington's, Parkinson's disease, and many Cancers and cancer-related syndromes. You can help by simply running a piece of software. Folding@home is a distributed computing project -- people from throughout the world download and run software to band together to make one of the largest supercomputers in the world. Every computer takes the project closer to our goals. Folding@home uses novel computational methods coupled to distributed computing, to simulate problems millions of times more challenging than previously achieved. We have had several successes. You can read about them on our Science page, on our Awards page, or go directly to our Results page. ... [Information of the supplier, modified]
LisBeth is a standalone computer program that implements the three-item analysis (3ia) for cladistic research in phylogenetics and biogeography. The development of the 3ia approach begun with the works of Gary Nelson, Norman Platnick, Pauline Ladiges (Nelson and Ladiges 1991; Nelson and Platnick 1991; Nelson and Ladiges 1992; Nelson and Ladiges 1996). Recent advances of the method are due to the research by David M. Williams and Malte C. Ebach among others. LisBeth is the only package of computer programs specially designed for three-item analysis (3ia), i.e. phylogenetics and cladistic biogeography. LisBeth graphic user interface (GUI), allows representing hypotheses of homology among taxa or areas directly as rooted trees or as hierarchies, i.e. as nested Venn diagrams. The GUI is used to enter, edit and visualize the hypotheses of homology and the results of their combination using 3ia. It allows a complete description of each character (each tree) and each state (each component of the tree). It may be used for systematics, and it is being adapted for cladistic biogeography. ... [Information of the supplier]
