The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products in different databases. The GO collaborators are developing three structured, controlled vocabularies (ontologies) that describe gene products in terms of their associated biological processes, cellular components and molecular functions in a species-independent manner. There are three separate aspects to this effort: first, we write and maintain the ontologies themselves; second, we make cross-links between the ontologies and the genes and gene products in the collaborating databases, and third, we develop tools that facilitate the creation, maintainence and use of ontologies. The use of GO terms by several collaborating databases facilitates uniform queries across them. The controlled vocabularies are structured so that you can query them at different levels: for example, you can use GO to find all the gene products in the mouse genome that are involved in signal transduction, or you can zoom in on all the receptor tyrosine kinases. This structure also allows annotators to assign properties to gene products at different levels, depending on how much is known about a gene product. ... [Information of the supplier]
The Nuclear Receptor Signaling Atlas (NURSA) was created to develop a comprehensive understanding of the structure, function, and role in disease of nuclear receptors. While the Atlas was begun as a Functional Atlas of Orphan Nuclear Receptors to elucidate the roles played by orphan nuclear receptors in metabolism and the development of metabolic disorders (including type 2 diabetes, obesity, osteoporosis, and lipid dysregulation), as well as in processes of aging and hormone-dependent cancers, the present goal of the Atlas consortium is to expand this effort to encompass all nuclear receptors. To accomplish these objectives, the members of the consortium form a team dedicated to catalyzing progress in understanding of the complex interplay between and among nuclear receptors and coregulators, with the goal of expediting translation of basic findings into tools that can find clinical applications. The goal is to approach research questions that require complex technologies which are not easily performed in an individual investigators laboratory, and in an interdisciplinary mode. The intent is to accumulate validated data, and to make it available rapidly to interested scientists at large via electronic communication on the NURSA website. Through this website, the Atlas is designed to reach out to all interested members of the nuclear receptor research community to provide new findings, access to new reagents, large validated data sets, a library of annotated prior publications in the field, and our e-journal, Nuclear Receptor Signaling. ... [Information of the supplier]
