BioMagResBank (BMRB) is the publicly-accessible depository for NMR results from peptides, proteins, and nucleic acids recognized by the International Society of Magnetic Resonance and by the IUPAC-IUBMB-IUPAB Inter-Union Task Group on the Standardization of Data Bases of Protein and Nucleic Acid Structures Determined by NMR Spectroscopy. In addition, BMRB provides reference information and maintains a collection of NMR pulse sequences and computer software for biomolecular NMR. Access to data in BMRB is free directly from its web site (URL http://www.bmrb.wisc.edu) and ftp site (ftp.bmrb.wisc.edu) and will remain so as public funding permits. The concept of a biomolecular NMR data bank was developed under a five-year research grant awarded to the University of Wisconsin-Madison from the National Library of Medicine, National Institutes of Health. ... [Information of the supplier]
Proteomik ist eine sehr junge Forschungsrichtung mit einer sehr viel älteren Wurzel: der Proteinanalytik. Diese befaßt sich mit der Aufklärung von molekularen Eigenschaften wie Aminosäuresequenz, dreidimensionale Struktur und biologische Aktivität individueller Proteine. Untersuchungsgegenstand der Proteomik ist demgegenüber die Gesamtheit aller Proteine in einer biologischen Probe im Moment der Untersuchung und bei den dafür gültigen Bedingungen. Dafür wurde vor etwa 7 Jahren der Begriff "Proteom" geprägt. Die DGPF versteht sich als Plattform, um die in Deutschland an verschiedenen Standorten und im Rahmen unterschiedlicher Programme angelaufenen Proteomik-Aktivitäten unter einem Dach zusammenzuführen und darüber hinaus die Proteomforschung durch national und international abgestimmte Initiativen voranzubringen. Durch eine übergreifende Koordination soll eine Bündelung und optimale Nutzung der nationalen Forschungs-kapazitäten herbeigeführt werden, um im weltweiten Wettbewerb an führender Stelle bestehen zu können. ... [Information des Anbieters]
M phase, also called as cell division, is the most crucial and fundamental affair of the eukaryotic cell cycle. After the chromosomes have been replicated during the S phase, the sister chromatids are separated and distributed into two daughter cells equally and faithfully. Also, each daughter cell receives the almost average and necessary intracellular constituents and organelles from the mother cell. Generally, cell division consists of six stages, including prophase, prometaphase, metaphase, anaphase, telophase and cytokinesis. And the first five stages constituent mitosis. During mitosis, numerous proteins organize protein super-complexes at the three distinct regions of centrosome, kinetochore/centromere and cleavage furrow/midbody. Although many proteins have been identified to be localized on centrosome, kinetochore and/or midbody, an integrated resource on this area still remains not to be available. In this work, we have collected all proteins identified to be localized on kinetochore, centrosome, and/or midbody from two fungi (S. cerevisiae and S. pombe) and five animals, including C. elegans, D. melanogaster, X. laevis, M. musculus and H. sapiens. From the related literature of PubMed, numerous proteins have been manually curated to be localized on at least one of the sub-cellular localizations of kinetochore, centrosome and midbody. And to promise the quality of data, based on the rationale of "Seeing is believing", these proteins have been unambiguously observed under fluorescent microscope as directly supportive evidences. Then an integrated and searchable database MiCroKit - Midbody, Centrosome and Kinetochore has been established. The MiCroKit database is the first integrative resource to pin point most of identified components and related scientific information of midbody, centrosome and kinetochore. The version 1.0 of MiCroKit database was set up on Nov. 2nd, 2005, containing 1,065 unique proteins. The MiCroKit version 2.0 was released on Jun. 5th, 2006, with 1,120 entries. Currently, the MiCroKit 3.0 database was updated on July 9, 2009, containing 1,489 unique protein entries. ... [Information of the supplier, modified]
