A comprehensive knowledge of all the factors involved in splicing, both proteins and RNAs, and of their interaction network is crucial for reaching a better understanding of this process and its functions. A large part of relevant information is buried in the literature or collected in various different databases. By hand-curated screenings of literature and databases we retrieved experimentally assessed data on 71 human RNA-binding splicing regulatory proteins and organized them into a database called “SpliceAid-F”. For each splicing factor (SF) the database reports its functional domains and its protein and chemical interactors. Furthermore, we collected experimentally validated RNA-SF interactions, including relevant information on the RNA binding sites such as the genes where these sites lie, their genomic coordinates, the splicing effects, experimental procedures, as well as the corresponding bibliographic references. We also collected information from experiments showing no RNA-SF binding, at least in the assayed conditions. In total, SpliceAid-F contains 4227 interactions, 2622 RNA binding sites and 1170 no-binding sites, including information on binding and no-binding specificity in different cellular contexts. Data collected in SpliceAid-F can provide significant information to explain an observed splicing pattern as well as the effect of mutations in functional regulatory elements. ... [Information of the supplier]
ChIPBase, an integrated resource and platform for decoding transcription factor binding maps, expression profiles and transcriptional regulation of long non-coding RNAs (lncRNAs, lincRNAs), microRNAs, other ncRNAs(snoRNAs, tRNAs, snRNAs, etc.) and protein-coding genes from ChIP-Seq data. ChIPBase currently includes millions of transcription factor binding sites (TFBSs) among 6 species. ChIPBase provides several web-based tools and browsers to explore TF-lncRNA, TF-miRNA, TF-mRNA, TF-ncRNA and TF-miRNA-mRNA regulatory networks. ... [Information of the supplier]
dbVar is a database of genomic structural variation that allows you to search, view, and download variant data from studies submitted for any organism. In general, variants are ≥ 50 nucleotides, but are occasionally smaller. dbVar provides access to the raw data (when available) and links to other NCBI and external resources. ... [Information of the supplier]
The Database of Genomic Variants archive (DGVa) is a repository that provides archiving, accessioning and distribution of publicly available genomic structural variants, in all species. In recent years there have been unprecedented advances in the technologies that characterise genomic variation, and it is well known that variation at the single nucleotide level is abundant across the genomes of all species. However, it is becoming clear that genomic structural variation - this is variation ranging from tens to millions of base pairs in size and includes insertions, deletions, inversions, translocations and locus copy number changes - accounts for more of the individual differences at the base pair level in humans and is likely to play a major role in disease. Two other areas of research that are becoming increasingly important in this field are discovering how genomic structural variation affects an individual's characteristics, and understanding the role it has played in the evolution of species. The DGVa catalogues, stores and freely disseminates this important class of variation in any species, providing a valuable resource to a large community of researchers. ... [Information of the supplier]
Human transcription factors are classified according to their DNA-binding domains. This classification is the working version that may be subject to occasional changes, suggested for discussion. A more robust version with a more flexible visualization has been made available using Jürgen Dönitz' OBA server. Moreover, it is also accessible in and used by the geneXplain platform. ... [Information of the supplier]
We present the Homo Sapiens Comprehensive Model Collection (HOCOMOCO) of transcription factor (TF) binding models obtained by careful integration of data from different sources. HOCOMOCO contains 426 non-redundant curated binding models for 401 human TFs. [Information of the supplier]
UCNEbase provides information on the evolution and genomic organization of ultra-conserved non-coding elements (UCNEs) in multiple vertebrate species. It currently covers 4351 such elements in 18 different species. Around half of these elements are located within intergenic regions (2’139) and the rest are located within non-coding parts of genes: introns (1’713) and UTRs (499). The majority of UCNEs are supposed to be transcriptional regulators of key developmental genes. ... [Information of the supplier]
The Murnau Conference on Structural Biology is the biannual meeting of the study group Structural Biology of the German Society for Biochemistry and Molecular Biology (GBM). Welcome to the homepage of the 5th Murnau Conference 2014, taking place in the beautiful scenery of the Alpine foothills of Bavaria. During three days in September of 2014, established leaders of the field and younger scientists will come together for discussions in a relaxed atmosphere. Besides lectures given by invited speakers, there is room for additional oral presentations and posters. Industry exhibitions and social events further complement the program. In the interest of fostering discussions and retaining a focused meeting, the number of participants will be restricted to a maximum of 200. ... [Information of the supplier]
The 2015 IMB Conference will explore cutting edge research in the fields of DNA repair and genome stability within chromatin environments.The conference will cover local chromatin events and their implications for genome stability, such as the functions of chromatin remodellers and posttranslational modifications in various DNA repair and damage signalling pathways.The global consequences of chromatin structure, such as the modulation of nuclear dynamics and the relevance of higher-order chromatin for accessibility and damage processing will also be explored.Scientific talks will be structured into the following themes: DNA damage signalling and checkpoint activation in chromatin,Influence of chromatin on damage processing and repair,Replication of chromatin in the presence of DNA damage,Chromatin dynamics and remodelling in response to DNA damage. The combined expertise represented by the panel of speakers who will present their unpublished research is expected to provide an environment to integrate newly emerging information into conceptual advances in the field. This conference will be a unique opportunity for all participants to learn about the latest discoveries, talk about their own findings and initiate research partnerships. We hope that the ideas and concepts developed during the conference will result in exciting collaborations. ... [Information of the supplier]
The Botanic Garden and Botanical Museum Berlin and the Museum für Naturkunde Berlin are glad to welcome you to the 2016 GGBN conference, held from June 21 through June 24, 2016, in Berlin, Germany. The Global Genome Biodiversity Network is a collaborative effort to cryo-preserve and provide access to genomic samples from across the Tree of Life. Sessions and Workshops are planned on: Concerted collecting and sampling strategies to preserve the Tree of Life; Sampling the lost world in Natural History collections; Nagoya Protocol: consequences and solutions; Knowledge exchange: natural history meets applied biobanking; and Implementing GGBN standards and best practices. ... [Information of the supplier]