ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided. ... [Information of the supplier]
Proteases are a diverse and important group of enzymes representing >2% of the human, chimpanzee, mouse and rat genomes. This group of enzymes is implicated in numerous physiological processes. The importance of proteases is illustrated by the existence of 80 different hereditary diseases due to mutations in protease genes. Furthermore, proteases have been implicated in multiple human pathologies, including vascular diseases, rheumatoid arthritis, neurodegenerative processes, and cancer. During the last ten years, our laboratory has identified and characterized more than 60 human protease genes. Due to the importance of proteolytic enzymes in human physiology and pathology, we have recently introduced the concept of Degradome, as the complete repertoire of proteases expressed by a tissue or organism. Thanks to the recent completion of the human, chimpanzee, mouse, and rat genome sequencing projects, we were able to analyze and compare for the first time the complete protease repertoire in those mammalian organisms, as well as the complement of protease inhibitor genes. This webpage is a repository of this information, as described in The Degradome database: mammalian proteases and diseases of proteolysis Nucleic Acids Res (2008). ... [Information of the supplier]
This internet database integrates information on sequence and structure of cytochrome P450 monooxygenases to facilitate protein engineering. We acknowledge your comments or contribution to this page: please send us information to be included in this database. [Information of the supplier]
ccPDB (Compilation and Creation of datasets from PDB) is designed to provide service to scientific community working in the field of function or structure annoation of proteins. This database of datasets is based on Protein Data Bank (PDB), where all datasets were derived from PDB. ccPDB have four modules; i) compilation of datasets, ii) creation of datasets, iii) web services and iv) Important links. Following is brief description of these modules. ... [Information of the supplier, modified]
The Characterized Protein Database, CharProtDB, is designed and being developed as a resource of expertly curated, experimentally characterized proteins described in published literature. For each protein record in CharProtDB, storage of several data types is supported. It includes functional annotation (several instances of protein names and gene symbols) taxonomic classification, literature links, specific Gene Ontology (GO) terms and GO evidence codes, EC (Enzyme Commisssion) and TC (Transport Classification) numbers and protein sequence. Additionally, each protein record is associated with cross links to all public accessions in major protein databases as ‘synonymous accessions’. Each of the above data types can be linked to as many literature references as possible. ... [Information of the supplier]
FunTree provides a range of data resources to detect the evolution of enzyme function within distant structurally related clusters within domain super families as determined by CATH. To access the resource enter a specific CATH superfamily code or search for a structure / sequence / function (either via a EC code or KEGG ligand / reaction ID, PDB ID or UniProtKB ID). Or browse the resource via superfamily / function / structure / metabolites & reactions via the menu on the left pannel. Further information about the process can be found on the HELP pages. ... [Information of the supplier]
No other database than ESTHER holds all alpha/beta hydrolase fold proteins together: Interpro, Prosite, Pfam, have multiple entries for subsets of this structural superfamily. A table Synthese shows the correspondance between these database entries and the subfamilies in ESTHER. The ESTHER Table is now a little to big to be usefull. Each file contains one of the 31219 non redundant proteins/genes. The tables grouped in the family table, the syntheses table or the structure table may be more usefull. The Gene_locus nomenclature for these non-redundant entries is a name with 5 characters for the organisms (3 for genera, 2 for the species, except when a common 5 character name exists. ex: ratno is for Rattus norvegicus and human for man. This allows us to keep close to the Swiss-Prot nomenclature). The last characters define the protein, ex: human-acche represents human acetylcholinesterase. ... [Information of the supplier]
Polbase(R) is an open repository of DNA polymerase information. The goals are: a) Provide a free and open information resource focused on DNA polymerases; b) Extract primary results from published and unpublished sources; c) Present results in context, without editorial bias, verified by authors; d) Create a polymerase-centric information hub by connecting with other protein resources (PubMed, PDB, UniProt, etc.); e) Be responsive to community suggestions; f) Remain current by automatically identifying newly published papers; g) Sustainability! By engaging the polymerase research community we can produce a valuable resource with minimal effort from any individual contributor The DNA Polymerase Database (Polbase) is intended to compile the wealth of existing DNA Polymerase information from public and private records into an open, searchable database. It supplements existing resources: a) PubMed; b) ExPASy; c) UniProtKB; d) RCSB PDB; e) KEGG; f) PROSITE; g) BRENDA; h) Human Polymerase Gamma Mutation Database. ... [Information of the supplier]
The study of helicases and translocases is a rapidly growing field, fuelled by the fact that helicase defects are associated with inherited human diseases including neurological disorders, cancer, and aging processes. Pathogens encode helicases, making these enzymes targets for new anti-viral or anti-bacterial therapies. New discoveries linking helicases to disease states are being discovered regularly, due to the fact that helicases and translocases participate in a wide variety of cellular functions. ... [Information of the supplier]
"Neuroguide.com" is a searchable and browsable index of neuroscience resources available on the Internet: Neurobiology, neurology, neurosurgery, psychiatry, psychology, cognitive science sites and information on human neurological diseases. [Information of the supplier]
