The UCSD-Nature Signaling Gateway is a comprehensive and up-to-the-minute resource for anyone interested in signal transduction. This Gateway represents a unique collaboration between the University of California San Diego (UCSD) and Nature Publishing Group and is designed to facilitate navigation of the complex world of research into cellular signaling. Information and data presented here are freely available to all. It is powered by the San Diego Supercomputer Center (SDSC). At the heart of this collaboration is the Molecule Pages, a relational database of all significant published qualitative and quantitative information on cell signaling proteins. This database will also allow entirely new insights to be gleaned through intelligent data mining: the Molecule Pages database was developed with the specific aim of allowing interactions, and indeed whole pathways, to be modeled. Our goal is to filter the data to present only validated information. Thus, invited experts will enter much of the data and every Molecule Page will be comprehensively peer reviewed by Nature. We regard a Molecule Page as a new full-fledged form of publication. ... [Information of the supplier]
hiPathDB provides two different types of integration. The pathway-level integration is a simple collection of individual pathways as described in the original database. We devised a gene-centric pathway model that could reflect different properties of four databases. The entity-level integration creates a super pathway that merged all pathways by unifying redundant components. Even though the detailed molecular information such as complex formation or modification can be lost in some cases, the merged superpathway provides a unified view of current knowledge on human pathways, which is critical to understand relationships among different pathways. Another strong merit of hiPathDB is the built-in pathway visualization module to support explorative study of complex networks in an interactive fashion. The force-directed layout algorithm is optimized for almost automatic visualization of pathways. ... [Information of the supplier]
Bluejay is a set of Java(TM) objects for the processing, display and querying of XML encoded linear scale data. The main subject for analysis in our implementation are genetic and protein sequences, where features fall somewhere on the linear molecules. Bluejay is growing with the goal of creating a graphical genetic data viewer with point-and-click data mining capabilities, such as those available through your standard Web browser. If the image to the left was animated when you first loaded this document, you should have all you need. Otherwise click on the image to obtain the Java Runtime Environment. Please see the publications for more details on Bluejay. ... [Information of the supplier]
MOLMOL is a molecular graphics program for displaying, analyzing, and manipulating the three-dimensional structure of biological macromolecules, with special emphasis on the study of protein or DNA structures determined by NMR. The program runs on UNIX and Windows NT/95/98/2000 and is freely available. [Information of the supplier]
Proteomik ist eine sehr junge Forschungsrichtung mit einer sehr viel älteren Wurzel: der Proteinanalytik. Diese befaßt sich mit der Aufklärung von molekularen Eigenschaften wie Aminosäuresequenz, dreidimensionale Struktur und biologische Aktivität individueller Proteine. Untersuchungsgegenstand der Proteomik ist demgegenüber die Gesamtheit aller Proteine in einer biologischen Probe im Moment der Untersuchung und bei den dafür gültigen Bedingungen. Dafür wurde vor etwa 7 Jahren der Begriff "Proteom" geprägt. Die DGPF versteht sich als Plattform, um die in Deutschland an verschiedenen Standorten und im Rahmen unterschiedlicher Programme angelaufenen Proteomik-Aktivitäten unter einem Dach zusammenzuführen und darüber hinaus die Proteomforschung durch national und international abgestimmte Initiativen voranzubringen. Durch eine übergreifende Koordination soll eine Bündelung und optimale Nutzung der nationalen Forschungs-kapazitäten herbeigeführt werden, um im weltweiten Wettbewerb an führender Stelle bestehen zu können. ... [Information des Anbieters]
Protein Spotlight is a monthly review written by the Swiss-Prot team of the Swiss Institute of Bioinformatics. Spotlight articles describe a specific protein or family of proteins on an informal tone. This site is hosted on ExPASy. [Information of the supplier, modified]
The Molecular Genetics Explorer is a BioQUEST software simulation that integrates genetics, biochemistry, and molecular biology to study a biological phenomenon. It is designed to show students the connections between these three key disciplines of modern molecular genetics. It is based on "Botstein's Triangle". [Information of the supplier]
The aim of this service is to provide an easy way to generate pictures and movies of protein structures, with the concern of integrating the most frequently used concepts of the molecular graphics fields via the software Dino. High definition pictures and movies are produced via the use of the Megapov engine founded on the Persistance of Vision Ray tracer - POV-Ray engine. This rendering engine is coupled with external programs such as stride (secondary structure determination), or msms (molecular surface calculation). This service can produce static images as well as movies illustrating macromolecular "docking", molecular dynamics, NMR model diversity and protein motions ... [Information of the supplier]
Welcome to FUNCRYPTA, the tardigrade project funded by the BMBF Framework Programme "Biotechnologie - Chancen nutzen und gestalten", "QuantPro - Quantitative Analyse zur Beschreibung dynamischer Prozesse in lebenden Systemen". The scientific objectives of FUNCRYPTA are:(i) to identify genes, enzymes and their products, whose value for stabilizing cells has been documented, on entering, during and after the anhydrobiotic stage in tardigrades, ii) to relate known dynamic cellular procedures during the anhydrobiotic stage in order to understand the background of anhydrobiotic changes, and(iii) to develop mathematical methods to understand and quantify mechanisms, dynamics and driving forces of anhydrobiosis in order to predict changes and to provide a scientific baseline for further investigation and development of products required to stabilize cells. ... [Information of the supplier]
Our goal: to understand protein folding, misfolding, and related diseases. Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out these important functions, they assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, in many ways remains a mystery. Moreover, when proteins do not fold correctly (i.e. "misfold"), there can be serious consequences, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, Huntington's, Parkinson's disease, and many Cancers and cancer-related syndromes. You can help by simply running a piece of software. Folding@home is a distributed computing project -- people from throughout the world download and run software to band together to make one of the largest supercomputers in the world. Every computer takes the project closer to our goals. Folding@home uses novel computational methods coupled to distributed computing, to simulate problems millions of times more challenging than previously achieved. We have had several successes. You can read about them on our Science page, on our Awards page, or go directly to our Results page. ... [Information of the supplier, modified]
