The European Nucleotide Archive (ENA) captures and presents information relating to experimental workflows that are based around nucleotide sequencing. A typical workflow includes the isolation and preparation of material for sequencing, a run of a sequencing machine in which sequencing data are produced and a subsequent bioinformatic analysis pipeline. ENA records this information in a data model that covers input information (sample, experimental setup, machine configuration), output machine data (sequence traces, reads and quality scores) and interpreted information (assembly, mapping, functional annotation). Data arrive at ENA from a variety of sources. These include submissions of raw data, assembled sequences and annotation from small-scale sequencing efforts, data provision from the major European sequencing centres and routine and comprehensive exchange with our partners in the International Nucleotide Sequence Database Collaboration (INSDC). ENA is made up of a number of distinct databases that includes EMBL-Bank, the newly established Sequence Read Archive (SRA) and the Trace Archive each with their own data formats and standards. ... [Information of the supplier]
The UCSD-Nature Signaling Gateway is a comprehensive and up-to-the-minute resource for anyone interested in signal transduction. This Gateway represents a unique collaboration between the University of California San Diego (UCSD) and Nature Publishing Group and is designed to facilitate navigation of the complex world of research into cellular signaling. Information and data presented here are freely available to all. It is powered by the San Diego Supercomputer Center (SDSC). At the heart of this collaboration is the Molecule Pages, a relational database of all significant published qualitative and quantitative information on cell signaling proteins. This database will also allow entirely new insights to be gleaned through intelligent data mining: the Molecule Pages database was developed with the specific aim of allowing interactions, and indeed whole pathways, to be modeled. Our goal is to filter the data to present only validated information. Thus, invited experts will enter much of the data and every Molecule Page will be comprehensively peer reviewed by Nature. We regard a Molecule Page as a new full-fledged form of publication. ... [Information of the supplier]
MfunGD provides a resource for annotated mouse proteins and their occurence in protein networks. Protein function annotation is performed using the Functional Catalogue (FunCat) annotation scheme, which is a hierarchically structured classification system (Ruepp et al., NAR, 2004). To provide up-to-date similarity search results and InterPro domain analyses, the protein entries are interconnected with the SIMAP database (Rattei et al., NAR, 2006). The gene models are based on the RefSeq mouse cDNAs (Pruitt et al., NAR, 2007) The work of our group is focussed on the annotation of biological systems. Therefore, results from the Mammalian Protein-Protein Interaction Database ( MPPI, (Pagel et al., Bioinformatics, 2005 )) and the Comprehensive Resource of Mammalian Protein Complexes (CORUM, (Ruepp et al., NAR, 2007)) are linked to the MfunGD dataset. Links to external resources are also provided (e.g. Refseq, Uniprot, UCSC Genome Browser). MfunGD is implemented in GenRE, a J2EE based component oriented multi-tier architecture (Mewes et al., NAR, 2006). ... [Information of the supplier]
The principal aims of the EGF are: a) to run the European School of Genetic Medicine, promoting the advanced scientific and professional training of young European Geneticists, with particular attention to the applications in the field of preventive medicine, b) to promote public education about genetics discoveries and c) to organize conferences, courses, international prizes and initiatives aimed at bringing together the scientific and humanistic disciplines. ... [Information of the supplier]
Completed in 2003, the Human Genome Project (HGP) was a 13-year project coordinated by the U.S. Department of Energy and the National Institutes of Health. During the early years of the HGP, the Wellcome Trust (U.K.) became a major partner; additional contributions came from Japan, France, Germany, China, and others. See our history page for more information. Project goals were to identify all the approximately 20,000-25,000 genes in human DNA, determine the sequences of the 3 billion chemical base pairs that make up human DNA, store this information in databases, improve tools for data analysis, transfer related technologies to the private sector, and address the ethical, legal, and social issues (ELSI) that may arise from the project. Though the HGP is finished, analyses of the data will continue for many years. Follow this ongoing research on our Progress page. ... [Information of the supplier]
A database is a model of a piece of the world. RegulonDB in this sense is a model of the complex regulation of transcription initiation or regulatory network of the cell, on the one hand. On the other hand, it is also a model of the organization of the genes in transcription units, operons and simple and complex regulons. In this sense, RegulonDB is a computational model of mechanisms of transcriptional regulation. ... [Information of the supplier]
Saccharomyces Genome Database is a scientific database of the molecular biology and genetics of the yeast Saccharomyces cerevisiae, which is commonly known as baker's or budding yeast. (...) SGD contains the sequences of yeast genes and proteins; descriptions and classifications of their biological roles, molecular functions, and subcellular localizations; links to literature information; links to functional genomics datasets; and tools for analysis and comparison of sequences. The SGD Home page is the main entry point for the database. SGD is aimed at scientists; collected information about yeast for the non-scientist can be found at the Yeast Virtual Library. SGD does not collect medical information, and SGD curators cannot answer health-related questions. ... [Information of the supplier]
Mouse Genome Informatics (MGI) provides integrated access to data on the genetics, genomics, and biology of the laboratory mouse. The projects contributing to this resource are: (1) Mouse Genome Database (MGD) Project; (2) Gene Expression Database (GXD) Project; (3) Mouse Tumor Biology (MTB) Database Project; (4) Gene Ontology (GO) Project. ... [Information of the supplier]
The primary goal of computational molecular biology, like molecular biology itself, is to understand the meaning of the genomic information and how this information is expressed. We are interested in the problems of predicting biological function of genes and gene products from their primary sequence and structure (sometimes known as functional genomics). We are interested in predicting structure of protein and DNA from its sequence, and understanding how and when genes are expressed. ... [Information of the supplier]
The new J. Craig Venter Institute was formed in October 2006 through the merger of several affiliated and legacy organizations--The Institute for Genomic Research (TIGR) and The Center for the Advancement of Genomics (TCAG), The J. Craig Venter Science Foundation, The Joint Technology Center, and the Institute for Biological Energy Alternatives (IBEA). Today all these organizations have become one large multidisciplinary genomic-focused organization. With more than 500 scientists and staff, more than 250, 000 square feet of laboratory space, and locations in Rockville, Maryland and La Jolla, California, the new JCVI is a world leader in genomic research. ... [Information of the supplier]
