This database presents the current results of large scale protein trapping screens that provide both information on which cells express each tagged gene, and subcellular localization of GFP-tagged proteins. It contains sequence coordinates of inserted transposons, information on the tagged genes, and images with expression patterns of GFP in Drosophila tissues. FlyTrap serves as the data repository for lines generated in the Chia, Cooley, and Spradling labs. The protein trap stocks listed in FlyTrap are available for distribution. ... [Information of the supplier, modified]
The goals of the Drosophila Genome Center are to finish the sequence of the euchromatic genome of Drosophila melanogaster to high quality and to generate and maintain biological annotations of this sequence. In addition to genomic sequencing, the BDGP is 1) producing gene disruptions using P element-mediated mutagenesis on a scale unprecedented in metazoans; 2) characterizing the sequence and expression of cDNAs; and 3) developing informatics tools that support the experimental process, identify features of DNA sequence, and allow us to present up-to-date information about the annotated sequence to the research community. ... [Information of the supplier]
ZFIN serves as the zebrafish model organism database. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic and developmental information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology and f) to serve the needs of the research community. ... [Information of the supplier]
Grid computing is regarded as one of the critical success factors in biomedical Research. The joint project MediGRID unifies well known research institutes in the area of medicine, biomedical informatics and life sciences into a consortium. Numerous associated partners from industry, healthcare and research facilities ensure a broad representation of these communities. The main goal of MediGRID is the Development of a Grid middleware integration platform enabling eScience services for biomedical life science. Therefore the consortium allocated the tasks in different modules. The four methodological modules (middleware, ontology, resource fusion and eScience) plan to incrementally develop and provide a Grid infrastructure while taking into account the need of the biomedical users. The user communities are represented in three research modules for biomedical informatics, image processing and clinical research. ... [Information of the supplier]
The JGI Genome Portal offers an interface to several bioinformatics tools for studying genomes. For each organism sequenced by JGI, a specific subset of tools is available. Throughout a subsite for a given organism, the navigation bar provides links to the tools available for that organism. [Information of the supplier, modified]
SOURCE is a unification tool which dynamically collects and compiles data from many scientific databases, and thereby attempts to encapsulate the genetics and molecular biology of genes from the genomes of Homo sapiens, Mus musculus, Rattus norvegicus into easy to navigate GeneReports. The mission of SOURCE is to provide a unique scientific resource that pools publicly available data commonly sought after for any clone, GenBank accession number, or gene. SOURCE is specifically designed to facilitate the analysis of large sets of data that biologists can now produce using genome-scale experimental approaches. Data on this page are curated from UniGene, Swiss-Prot, GeneMap99, RHdb, and Entrez Gene. ... [Information of the supplier]
VectorBase is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates and maintains vector genomes providing an integrated resource for the research community. Currently, VectorBase contains genome information for two organisms: Anopheles gambiae, a vector for the Plasmodium protozoan agent causing malaria, and Aedes aegypti, a vector for the flaviviral agents causing Yellow fever and Dengue fever. (Lawson, D. et al., 2007: VectorBase: a home for invertebrate vectors of human pathogens. - Nucleic Acids Research 35: D503-D505; doi:10.1093/nar/gkl960.) ... [Information of the supplier]
Proteases are a diverse and important group of enzymes representing >2% of the human, chimpanzee, mouse and rat genomes. This group of enzymes is implicated in numerous physiological processes. The importance of proteases is illustrated by the existence of 80 different hereditary diseases due to mutations in protease genes. Furthermore, proteases have been implicated in multiple human pathologies, including vascular diseases, rheumatoid arthritis, neurodegenerative processes, and cancer. During the last ten years, our laboratory has identified and characterized more than 60 human protease genes. Due to the importance of proteolytic enzymes in human physiology and pathology, we have recently introduced the concept of Degradome, as the complete repertoire of proteases expressed by a tissue or organism. Thanks to the recent completion of the human, chimpanzee, mouse, and rat genome sequencing projects, we were able to analyze and compare for the first time the complete protease repertoire in those mammalian organisms, as well as the complement of protease inhibitor genes. This webpage is a repository of this information, as described in The Degradome database: mammalian proteases and diseases of proteolysis Nucleic Acids Res (2008). ... [Information of the supplier]
The Fish Barcode of Life effort is creating a valuable public resource in the form of an electronic database containing DNA barcodes, images, and geospatial coordinates of examined specimens. The database contains linkages to voucher specimens, information on species distributions, nomenclature, authoritative taxonomic information, collateral natural history information and literature citations. FISH-BOL thus complements and enhances existing information resources, including FishBase and various genomics databases. ... [Information of the supplier]
Ascertaining when and where genes are expressed is of crucial importance in order to understand the physiological role of a given gene/protein and the interactions between them. In addition, the normal expression patterns can then be compared to those observed in a variety of pathological conditions to identify pathological hallmarks of gene expression. The EURExpress, an integrated project funded by the EU under the VI Framework proposes a transcriptome-wide acquisition of expression patterns chiefly by means of in situ hybridization (ISH) with non-radioactive probes and will use this data to establish a web-linked, interactive digital transcriptome atlas of embryonic mouse. The final goal of the project is to create the expression data of > 20,000 genes by RNA in situ hybridization on sagittal sections from E14.5 wild type murine embryos. This data will result in a detailed description (at a cellular level) of gene expression patterns in the developing mouse. The “transcriptome atlas” will be generated using a newly developed automated RNA in situ hybridization system. Automated scanning microscopes will collect image data, which will be electronically sent out in a digital format for annotation. The latter will be performed using a web-based “virtual” microscope and be entered in a hierarchical database specifically designed to hold large amounts of image data and display them in a user-friendly format. For a subset of genes, mainly those directly involved in human diseases, expression data will also be generated by using human and murine tissue arrays. This will offer the opportunity to compare human and mouse expression patterns in adult tissues. This project builds on a strong European concentration of skills in gene expression analysis and mouse genomics and integrates European skills, efforts, resources and information in the field of systematic gene expression analysis. All expression data generated by EURExpress will be made readily available to the scientific community via the EURExpress web-linked database, considerably advancing our knowledge of gene function and having a significant impact on the identification of gene expression markers of disease processes. ... [Information of the supplier]
