FlyView is an image database on Drosophila development and genetics, especially on expression patterns of genes (enhancer trap lines, cloned genes). Our aim is to establish the possibility to compare images on the computer screen and to search for special patterns at different developmental stages. FlyView presents three possibilities for searching: Search for pattern elements (with keywords in text descriptions, getting back images with links to the appropriate stocks), search for stocks (with stock number, allele, genotype, chromosome, insertion site, viability, developmental stage or expression pattern, getting back a list of found stocks that guide to full descriptions (including links to images, e-mail address for ordering and, in the case of BDGP lines, also direct links to FlyBase and/or EofD)) and Overview (an actual list of all lines included in FlyView, linked to stock descriptions and images). The success of this database exclusively depends on the activity of the Drosophila community. All Drosophila workers are asked to contribute to this database by submitting images and accompanying text. ... [Information of the supplier, modified]
This database presents the current results of large scale protein trapping screens that provide both information on which cells express each tagged gene, and subcellular localization of GFP-tagged proteins. It contains sequence coordinates of inserted transposons, information on the tagged genes, and images with expression patterns of GFP in Drosophila tissues. FlyTrap serves as the data repository for lines generated in the Chia, Cooley, and Spradling labs. The protein trap stocks listed in FlyTrap are available for distribution. ... [Information of the supplier, modified]
The goals of the Drosophila Genome Center are to finish the sequence of the euchromatic genome of Drosophila melanogaster to high quality and to generate and maintain biological annotations of this sequence. In addition to genomic sequencing, the BDGP is 1) producing gene disruptions using P element-mediated mutagenesis on a scale unprecedented in metazoans; 2) characterizing the sequence and expression of cDNAs; and 3) developing informatics tools that support the experimental process, identify features of DNA sequence, and allow us to present up-to-date information about the annotated sequence to the research community. ... [Information of the supplier]
ZFIN serves as the zebrafish model organism database. The long term goals for ZFIN are a) to be the community database resource for the laboratory use of zebrafish, b) to develop and support integrated zebrafish genetic, genomic and developmental information, c) to maintain the definitive reference data sets of zebrafish research information, d) to link this information extensively to corresponding data in other model organism and human databases, e) to facilitate the use of zebrafish as a model for human biology and f) to serve the needs of the research community. ... [Information of the supplier]
Grid computing is regarded as one of the critical success factors in biomedical Research. The joint project MediGRID unifies well known research institutes in the area of medicine, biomedical informatics and life sciences into a consortium. Numerous associated partners from industry, healthcare and research facilities ensure a broad representation of these communities. The main goal of MediGRID is the Development of a Grid middleware integration platform enabling eScience services for biomedical life science. Therefore the consortium allocated the tasks in different modules. The four methodological modules (middleware, ontology, resource fusion and eScience) plan to incrementally develop and provide a Grid infrastructure while taking into account the need of the biomedical users. The user communities are represented in three research modules for biomedical informatics, image processing and clinical research. ... [Information of the supplier]
The JGI Genome Portal offers an interface to several bioinformatics tools for studying genomes. For each organism sequenced by JGI, a specific subset of tools is available. Throughout a subsite for a given organism, the navigation bar provides links to the tools available for that organism. [Information of the supplier, modified]
SOURCE is a unification tool which dynamically collects and compiles data from many scientific databases, and thereby attempts to encapsulate the genetics and molecular biology of genes from the genomes of Homo sapiens, Mus musculus, Rattus norvegicus into easy to navigate GeneReports. The mission of SOURCE is to provide a unique scientific resource that pools publicly available data commonly sought after for any clone, GenBank accession number, or gene. SOURCE is specifically designed to facilitate the analysis of large sets of data that biologists can now produce using genome-scale experimental approaches. Data on this page are curated from UniGene, Swiss-Prot, GeneMap99, RHdb, and Entrez Gene. ... [Information of the supplier]
VectorBase is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates and maintains vector genomes providing an integrated resource for the research community. Currently, VectorBase contains genome information for two organisms: Anopheles gambiae, a vector for the Plasmodium protozoan agent causing malaria, and Aedes aegypti, a vector for the flaviviral agents causing Yellow fever and Dengue fever. (Lawson, D. et al., 2007: VectorBase: a home for invertebrate vectors of human pathogens. - Nucleic Acids Research 35: D503-D505; doi:10.1093/nar/gkl960.) ... [Information of the supplier]
The HuGE Literature Finder is one component of the HuGE Navigator, an integrated, searchable knowledge base of genetic associations and related information in human genome epidemiology. In 2001, HuGENet launched the HuGE Published Literature database (HuGE Pub Lit), a continually updated and accessible knowledge base on the World Wide Web that tracks the growing published literature of human genome epidemiologic studies. HuGE Pub Lit offers a starting point for assembling articles for meta-analysis, highlighting research gaps, suggesting applied research questions, and identifying potential collaborators. HuGE Pub Lit contains links to abstracts on PubMed that meet the inclusion and exclusion criteria (see below). HuGENet research staff is responsible for extracting relevant articles from PubMed and entering them into the HuGE Pub Lit database on a weekly basis. Since June 2007, a new automatic HuGE literature screening – GAPscreener was implemented to assist the weekly HuGE literature scanning from PubMed. The sensitivity of HuGE literature screening performance can reach 97.5%. An average of 500 new articles per week is retrieved by GAPscreener. A researcher who is familiar with the eligibility criteria for human genome epidemiology then reviews each title and abstract (or in a few cases, the full text). This researcher decides whether the study will be included in the database and, if it will, assigns indexing for each article. HuGE Literature Finder is a newly-designed HuGE Pub Lit database that utilizes the Unified Medical Language System (UMLS) as an indexing mechanism. ... [Information of the supplier]
Proteases are a diverse and important group of enzymes representing >2% of the human, chimpanzee, mouse and rat genomes. This group of enzymes is implicated in numerous physiological processes. The importance of proteases is illustrated by the existence of 80 different hereditary diseases due to mutations in protease genes. Furthermore, proteases have been implicated in multiple human pathologies, including vascular diseases, rheumatoid arthritis, neurodegenerative processes, and cancer. During the last ten years, our laboratory has identified and characterized more than 60 human protease genes. Due to the importance of proteolytic enzymes in human physiology and pathology, we have recently introduced the concept of Degradome, as the complete repertoire of proteases expressed by a tissue or organism. Thanks to the recent completion of the human, chimpanzee, mouse, and rat genome sequencing projects, we were able to analyze and compare for the first time the complete protease repertoire in those mammalian organisms, as well as the complement of protease inhibitor genes. This webpage is a repository of this information, as described in The Degradome database: mammalian proteases and diseases of proteolysis Nucleic Acids Res (2008). ... [Information of the supplier]