H-DBAS is a unique database of alternative splicing (AS) based on H-InvDB. The features of H-DBAS is as follows: 1) Representative AS variants (RASVs) were identified from 8 data sets consist of 6 mammalian model organisms (human, mouse, rat, chimpanzee, macaque and dog). The contents of data sets and the corresponding species are as follows: Full-length cDNA data set, mRNA data set, RNA data set 2) Equally-spliced variants (ESVs) were identified from RASVs between human and mouse, rat, chimpanzee, macaque and dog by using comparative genomics. Splice sites and splice motifs affecting SNPs can be observed in human. 3) RASVs affecting protein functions (protein motif, GO, subcellular localization signal and transmembrane domain) can be observed in human. 4) AS junctions expressed in specified cellular fractions (cytoplasm, nuclear and polysome) of human cell were detected by using RNA-Seq tags. The translation validation of the variants having AS junctions were analyzed by compared with RefSeq junctions. The results are shown from RNA-Seq analysis page. ... [Information of the supplier]
Genetics Home Reference is the National Library of Medicine's Web site for consumer information about genetic conditions and the genes or chromosomes associated with those conditions. You can find Genetic Condition Summaries, Gene Summaries, Gene Family Summaries, Chromosome Summaries, a Handbook and a Glossery on this website. Furthermore there are several learning activities available to help you explore the website and find out about human genetics. ... [Information of the supplier, modified]
The Genetic Association Database is an archive of human genetic association studies of complex diseases and disorders. The goal of this database is to allow the user to rapidly identify medically relevant polymorphism from the large volume of polymorphism and mutational data, in the context of standardized nomenclature. ... [Information of the supplier]
In September, 2001, the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) convened a working group of its National Advisory Council to develop a strategic plan for Stem Cells and Developmental Biology. The working group made several recommendations, with the overall goals of providing new strategies for repairing or replacing damaged organs and generating new insights into pathologic processes underlying developmental defects and disease. There is the need for a more thorough understanding of organogenesis so that tissue degeneration and congenital malformations might be prevented and treated. The goal of GUDMAP is a fundamental description of the developing kidney and GU tract. The panel recommended that the following three objectives be combined to form the GUDMAP. a) High throughput in situ hybridization analyses to define the expression pattern of genes expressed in the developing kidney and GU tract, b) High resolution gene expression analyses to define gene expression during developmental time, the overlap in gene expression patterns, and the correlation between boundaries of gene expression and boundaries of anatomic or functional domains and c) Development of a database to house and annotate the above data and to provide rapid access of this data to the entire research community. Microarray analyses and the generation of murine strains with genetic markers are also goals of GUDMAP which serve to bolster the overall aim of defining molecular and cellular anatomy through developmental time. ... [Information of the supplier, modified]
Launched in 1993, Access Excellence is a national educational program that provides high school health and biology teachers access to their colleagues, scientists, and critical sources of new scientific information via the World Wide Web. In 1999, Access Excellence was donated to the National Health Museum by Genentech, a leading biotechnology company. Access Excellence currently forms the core of the educational component of the National Health Museum Website and will be expanded substantially to better serve the needs of K-12 health educators. ... [Information of the supplier]
GeneCards® is an integrated database of human genes that includes automatically-mined genomic, proteomic and transcriptomic information, as well as orthologies, disease relationships, SNPs, gene expression, gene function, and service links for ordering assays and antibodies. [Information of the supplier]
Das Hauptziel der Webpräsenz ist die Bereitstellung allgemeinverständlicher Informationen rund um das menschliche Auge. Unter Vermeidung eines medizinischen "Fachchinesisch" sollen Laien verschiedene Aspekte des Themas kennenlernen können, wobei der Schwerpunkt auf augenfachärztlichen Themen liegt. Aber auch die biologischen Grundlagen des menschlichen Sehens werden durch Texte und Abbildungen erläutert. ... [Redaktion vifabio]
This website aims to provide you with key information about the human genome: the science, its role in health and medicine, and the broader social impact of unravelling its mysteries. The site is produced by the Wellcome Trust, the independent research funding charity that aims to improve human and animal health. [Information of the supplier]
Diese Website, ein Angebot des dänischen Lundbeck Instituts, gibt einen kompakten Überblick über biologische und medizinische Aspekte des menschlichen Denkorgans, dem Gehirn. Der "Brain Explorer" bietet neben allgemeinen Textinformationen und Abbildungen auch einige spezielle Videobeiträge zu den wichtigen Botenstoffen Noradrenalin und Serotonin. ... [Redaktion vifabio]
An international research consortium has been formed to create the most detailed and medically useful picture to date of human genetic variation. The 1000 Genomes Project will involve sequencing the genomes of at least a thousand people from around the world. The project will receive major support from the Wellcome Trust Sanger Institute in Hinxton, England, the Beijing Genomics Institute Shenzhen in China and the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH). Drawing on the expertise of multidisciplinary research teams, the 1000 Genomes Project will develop a new map of the human genome that will provide a view of biomedically relevant DNA variations at a resolution unmatched by current resources. As with other major human genome reference projects, data from the 1000 Genomes Project will be made swiftly available to the worldwide scientific community through freely accessible public databases. ... [Information of the supplier]
