This site contains all of the data from our ongoing proteomic analysis of human nucleoli, which is carried out as a collaboration between the Lamond and Mann laboratories (in Denmark and Munich). Using high sensitivity mass spectrometry and stringent criteria, we have so far identified ~700 human nucleolar proteins. More recently, we used a quantitative proteomic approach for the temporal characterization of protein flux through the nucleolus, determining the kinetics of up to 489 nucleolar proteins after various drug treatments and demonstrating that there is no unique, complete proteome for the nucleolus, but rather an overlapping set of proteomes that are relevant to different cell states or conditions. ... [Information of the supplier]
Antimicrobial peptides, also referred to as host defense peptides or "alarmins", have been identified in nearly all life forms, ranging from bacteria, fungi, plants, insects, amphibians, to mammals, including humans. As the key component of the innate immunity, these ancient peptides effectively eliminate invanding microbes such as bacteria, viruses, fungi, and parasites. It is commonly believed that cationic antimicrobial peptides exert their effects via attacking anionic bacterial membranes. Currently, there is high interest worldwide in this topic with a goal of understanding the mechanism of action and developing natural antimicrobial peptides into a new generation of antibiotics. To promote the research, education, and information exchange in the field, we have created this antimicrobial peptide database and data analysis system. The data stored in APD2 were gleaned from the Protein Data Bank (PDB), Swiss-Prot Protein Knowledgebase and PubMed National Library of Medicine. The peptides in this database are in the mature and active form and primarily from natural sources ranging from bacteria, plants, insects, to animals. ... [Information of the supplier]