We present a neural network based method (ChloroP) for identifying chloroplast transit peptides and their cleavage sites. Using cross-validation, 88% of the sequences in our homology reduced training set were correctly classified as transit peptides or nontransit peptides. This performance level is well above that of the so far only publicly available chloroplast localization predictor PSORT. Cleavage sites are predicted using a scoring matrix derived by an automatic motif-finding algorithm. Approximately 60% of the known cleavage sites in our sequence collection were predicted to within +- 2 residues from the cleavage sites given in SWISS-PROT. An analysis of 715 A. thaliana sequences from SWISS-PROT suggests that the ChloroP method should be useful for the identification of putative transit peptides in genome-wide sequence data. ... [Information of the supplier]
The scientific program for Signalling 2013 - from Structure to Function, is designed to represent the cutting edge of modern signal transduction research. By including diverse, yet interrelated, topics this keystone meeting will demonstrate how cell signalling continues to underpin key advances in biological and medical research in the 21st century. Topics: Second messengers, REDOX signalling, Small molecule inhibitors, Inflammation, Cancer, Ubiquitin, Lipid and protein kinases and Ion channels. ... [Information of the supplier]
The American Society for Cell Biology will hold its annual meeting in december 2013 in New Orleans. As the premier international meeting in the field of cell biology, the ASCB Annual Meeting is intended for scientists and students in academia, industry, government, and higher education. Over 100 scientific sessions and 2,500 poster presentations cover a variety of scientific areas within the discipline. With opportunities to learn about the latest research and network with peers, the ASCB Annual Meeting appeals to the diverse interests of the international cell biology community. ... [Information of the supplier]
By the time scientists arrive in San Diego in December 2015, an estimated 40,000 papers on cell biology will have been published since the 2014 meeting. Even more data will be available on imaging, protein structures, genomics, gene expression, and more. Our challenge is to convert this information into meaningful knowledge to understand how cells work. The 2015 ASCB meeting overarching theme is about making connections at different scales, from the intracellular level to the tissue level, to the organism level all the way up to the macrocosmic level, all in the light of big data and information integration. This integration will help us ask the right questions and find answers to the challenging problems in medicine, living systems, and ecosystems. Cell biology is increasingly relevant not only to those who think of themselves as cell biologists but also to more specialized researchers in neuroscience, immunology, cancer biology, synthetic biology, biophysics, molecular medicine, and more. ... [Information of the supplier, modified]