Organs and organelles represent core biological systems in mammals, but the diversity in protein composition remains unclear. Here, we combine subcellular fractionation with exhaustive tandem mass spectrometry-based shotgun sequencing to examine the protein content of four major organellar compartments (cytosol, membranes [microsomes], mitochondria and nuclei) in six organs (brain, heart, kidney, liver, lung and placenta) of the laboratory mouse, Mus musculus. Using rigorous statistical filtering and machine-learning methods, the subcellular localization of 3274 of the 4768 proteins identified was determined with high-confidence, including 1503 previously uncharacterized factors, while tissue-selectivity was evaluated by comparison to previously reported mRNA expression patterns. This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal. ... [Information of the supplier]
Protein phosphorylation is a post-translational modification that regulates an astonishing number of critical biological processes in multicellular organisms. Cellular protein phosphorylation is an enormously complex dynamic system: over 510 distinct protein kinases and 100 phosphoprotein phosphatases are encoded in the human genome, and upwards of 40% of cellular proteins may be phosphorylated during some stage of growth and differentiation. Many proteins are multiply phosphorylated on scores of sites, making it likely that there are minimally 100,000 distinct phosphorylation sites in the mammalian proteome. It is the intention of the scientists who are designing and implementing PhosphoSite to provide an accurate and comprehensive source of information about mammalian protein phosphorylation sites. Our goal is to identify and organize information about all in vivo phosphorylation sites in human and mouse proteomes and to provide information and resources that will facilitate phosphorylation research. PhosphoSite is a curated, sequence-oriented protein database dedicated to in vivo phosphorylation sites. Information in PhosphoSite version 1.0 includes: (a) The phosphorylated residue and its surrounding sequence. We consider this information to be the central, organizing feature of PhosphoSite. (b) Orthologous sites in other species; this should assist investigators in determining if a phosphorylation site in species A might also be phosphorylated in species B. (c) The location within domains and motifs; this should assist investigators in inferring possible biological functions of phosphorylation sites. (d) Links to other online resources including the Alliance for Cell Signaling, the Protein Kinase Resource, and Scansite. Scansite predicts likely sites for protein phosphorylation by particular kinases and likely sites for interaction with other signaling proteins. This information, based upon vitro data, will be highly complimentary to that provided by PhosphoSite. (e) Literature references which demonstrate the in vivo nature and significance of the phosphorylation site. (...) Curated information will come from literature reports as well as from high-throughput phosphosite discovery programs. Information extracted from the public domain will be freely available for educational users. Proprietary information from phosphorylation site discovery programs may be available on a subscription basis. Corporations will need to pay a reasonable yearly fee to legally access PhosphoSite. ... [Information of the supplier, modified]
This collection features approximately 4500 full page plates and other significant illustrations of human anatomy selected from the Jason A. Hannah and Academy of Medicine collections in the history of medicine at the Thomas Fisher Rare Book Library, University of Toronto. Each illustration has been fully indexed using medical subject headings (MeSH), and techniques of illustration, artists, and engravers have been identified whenever possible. There are ninety-five individual titles represented, ranging in date from 1522 to 1867. ... [Information of the supplier]
This Volume of animal placentas was created to assist with the examination and evaluation of the many different types of mammalian placentas. [Information of the supplier]
Das Tierlexikon ist die Website einer Privatperson, die ihr zusammen getragenes Wissen über Tiere mit Schwerpunkt Säugetiere zur Verfügung stellt. [Redaktion vifabio]
Embryo Images Normal and Abnormal Mammalian Development is a tutorial that uses scanning electron micrographs (SEMs) as the primary resource to teach mammalian embryology. The 3-D like quality of the micrographs coupled with selected line drawings and minimal text allow relatively easy understanding of the complex morphological changes that occur in utero. Because early human embryos are not readily available and because embryogenesis is very similar across mammalian species, the majority of micrographs that are utilized in this tutorial are of mouse embryos. The remainder are human. ... [Information of the supplier]
The Mammal Species of the World (MSW) is a database of mammalian taxonomy. It is hoped that this database on the World Wide Web can be used as a convenient on-line reference for identifying or verifying recognized scientific names and for taxonomic research. The names are organized in a hierarchy that includes Order, Family, Subfamily, Genus and Species. ... [Information of the supplier]
Online Mendelian Inheritance in Animals (OMIA) is a database of genes, inherited disorders and traits in more than 135 animal species (other than human and mouse) authored by Professor Frank Nicholas of the University of Sydney, Australia, with help from many people over the years. The database contains textual information and references, as well as links to relevant PubMed and Gene records at the NCBI. ... [Information of the supplier]
Mammalian Species is published, on line, regularly by the American Society of Mammalogists with 20-30 new accounts issued each year. Each account summarizes the current understanding of the biology of a single species, including systematics, distribution, fossil history, genetics, anatomy, physiology, behavior, ecology, and conservation. The accounts vary from 2 to 14 pages. The accounts are provided to members of the American Society of Mammalogists as a benefit of membership. ... [Information of the supplier]
The following table contains names of mammalia in three languages - German, Latin and English. I hope this will be useful for students both in Germany and all over the world where English is spoken. [Information of the supplier]
