Uptake of foreign mobile genetic elements is often detrimental and can result in cell death. For protection against invasion, prokaryotes have developed several defence mechanisms, which take effect at all stages of infection. The most recent discovered defence system is the prokaryotic immune system, termed CRISPR/Cas. This defence system directly degrades invading genetic material and is present in almost all archaea and many bacteria. Current data indicate a large variety in their mechanistic molecular approaches. This meeting is the 3rd European CRISPR Meeting after the previous meetings in Wageningen 2010 (organised by John van der Oost, Stan Brouns, Edze Westra, Philippe Horvath) and in St. Andrews 2013 (organised by Malcolm White, John van der Oost, Emanuelle Charpentier). The meeting is sponsored by the DFG Research Group "Unravelling the prokaryotic immune system" (FOR1680). Leading international experts on CRISPR/Cas will give lectures, additional oral presentations will be selected from submitted abstracts. Poster presentations will give scientists the opportunity to discuss their current work. Sessions will cover the following topics: evolution of the CRISPR/Cas system, CRISPR/Cas systems I-III, virus-host interactions and applications and Genome Editing and CRISPRi. ... [Information of the supplier]
In the 50 years since RNA was identified as a central component in the flow of genetic information, it has become increasingly clear that RNA is more than a mere messenger and performs many diverse and interesting functions. This symposium will explore the diverse, dynamic and multifaceted roles of RNA across a spectrum of cellular processes. Yet, framed in interdisciplinary discussion of the roles of non-coding RNAs with the aim of enhancing our understanding of gene regulation and function. Topics will include recent discoveries in the fields of prokaryotic and eukaryotic long and short non-coding RNAs. Collectively aiming to further understand the noncoding RNA transcriptional and regulatory landscape. ... [Information of the supplier, modified]
The increasing amount of genome-related data is a fruitful source for biological research. By comparing complete or partial genomes it is possible to infer a great amount of new biological information, including gene function, evolutionary relationship between species and ancestral genome organization. Due to the dimension of the available data, efficient computational tools are imperative to accomplish these tasks. The RECOMB-CG satellite conference brings together leading researchers in the mathematical, computational and life sciences to discuss cutting edge research in comparative genomics, with an emphasis on computational approaches and novel experimental results. The program includes both invited speakers and contributed talks. ... [Information of the supplier]
There has been tremendous progress in the past few years regarding our understanding of DNA replication in eukaryotes, both yeast and mammals. Many important questions in the field are poised to be answered within the next decade. These include understanding DNA replication at the biochemical and three-dimensional protein structure levels. In addition, studies using high throughput technologies at the cellular and organismal levels are poised to answer how accurate replication of the genome is ensured by controlling origin firing in space and time. Several human diseases, including cancer, have already been linked to DNA replication stress, a term that refers to perturbations in DNA replication. Therefore, a better understanding of how cells respond to this will help us understand disease development and responses to therapy. By bringing together experts in the basic biology of DNA replication and DNA replication stress, this symposium aims to fuel further progress in these important fields. ... [Information of the supplier]