The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body. It is intended to be used for applications in metabolomics, clinical chemistry, biomarker discovery and general education. The database is designed to contain or link three kinds of data: 1) chemical data, 2) clinical data, and 3) molecular biology/biochemistry data. The database currently contains nearly 2500 metabolite entries including both water-soluble and lipid soluble metabolites as well as metabolites that would be regarded as either abundant (> 1 uM) or relatively rare (< 1 nM). ... [Information of the supplier]
The word "aging" encompasses a range of physiological changes in humans, human tissues, and constituent cells. Alterations in metabolism, whether at the level of small molecules, protein homeostasis, signaling patterns, or intertissue communication, underpin many of the processes that ultimately decline or shift during aging. The recent wealth of information on how perturbation of metabolic factors can accelerate or impair aging processes makes this an exciting time to convene and consider the new biology being uncovered, its potential impact on human health, and the implications for the coming age of precision medicine. This meeting brings together scientists who have interests in aging and metabolism to explore the growing intersection between these fields and to discuss key questions in this area for human health and disease. Leaders in the field will share results from cellular research, investigations in model organisms, and studies with translational impact rooted in mammalian systems. ... [Editorial staff vifabio]
The field of immunometabolism has thrived over the last decade, revealing not only the major roles played by immune cells in metabolic homeostasis but also the impact of metabolic pathways on immune cell function. As new discoveries continue to reveal the intricate links between immunology and metabolism, a key question arises: will our accumulated knowledge on immunometabolic deregulations translate into novel therapies for human diseases? During this Cell Symposium, you will hear about the latest advances in immunometabolism from physician-scientists, basic researchers and industry leaders. We will discuss how local and systemic metabolism are integrated at the cellular level to regulate immune cell function and we will focus on how novel insights into immunometabolism can be harnessed to advance and/or bolster therapeutic interventions in metabolic diseases, inflammation, autoimmunity, and cancer. ... [Information of the supplier]
This meeting brings together scientists who have interests in aging, metabolism, and immunology to explore the growing intersection between these fields and to discuss key questions and important areas of future investigation. Our aim is to spur the progress of efforts to elucidate the mechanisms underlying the aging process, so as to inform current approaches of disease treatment and prevention, and to provide an improved understanding of healthy aging. ... [Information of the supplier]
