GoPubMed retrieves PubMed abstracts for your search query, detects Gene Ontology (GO) terms in the abstracts, displays a subset of the GO relevant to the keywords, and allows you to browse the ontology and display only papers containing specific GO terms. After performing a search, the resulting abstracts are annotated with your query keywords and GO terms. The abstracts are grouped using the GO terms, which appear in the text. Now you can use the GO hierarchy to systematically explore your search results. ... [Information of the supplier]
The field of immunometabolism has thrived over the last decade, revealing not only the major roles played by immune cells in metabolic homeostasis but also the impact of metabolic pathways on immune cell function. As new discoveries continue to reveal the intricate links between immunology and metabolism, a key question arises: will our accumulated knowledge on immunometabolic deregulations translate into novel therapies for human diseases? During this Cell Symposium, you will hear about the latest advances in immunometabolism from physician-scientists, basic researchers and industry leaders. We will discuss how local and systemic metabolism are integrated at the cellular level to regulate immune cell function and we will focus on how novel insights into immunometabolism can be harnessed to advance and/or bolster therapeutic interventions in metabolic diseases, inflammation, autoimmunity, and cancer. ... [Information of the supplier]
The EBI provides access to many different types of biological databases. The following is a brief summary of the types of databases available and the tools which can be used to query these database for various biological data. [Information of the supplier]
The Jena Library of Biological Macromolecules (JenaLib) is aimed at a better dissemination of information on three-dimensional biopolymer structures with an emphasis on visualization and analysis. It provides access to all structure entries deposited at the Protein Data Bank (PDB) or at the Nucleic Acid Database (NDB). In addition, basic information on the architecture of biopolymer structures is available. The JenaLib intends to fulfill both scientific and educational needs. ... [Information of the supplier]
The Biomolecular Structure and Modelling group brings together groups which derive protein structural information using crystallography or NMR, those who manage databases of structural information and analysts and modellers who examine these structures to derive principles of protein folding. [Information of the supplier]
The CrossFire Beilstein database is the world's largest compilation of chemical facts. As the cornerstone database to organic chemistry, the CrossFire Beilstein database is essential for generating new leads, planning synthetic routes (including starting materials and intermediates), determining bioactivity and physical properties and ascertaining the environmental fates of compounds. ... [Information of the supplier]
The Biological Macromolecule Crystallization Database (BMCD) contains crystal data and the crystallization conditions, which have been compiled from literature. The current version of the BMCD includes 5247 crystal entries from macromolecules for which diffraction quality crystals have been obtained. These include proteins, protein:protein complexes, nucleic acid, nucleic acid:nucleic acid complexes, protein:nucleic acid complexes, and viruses. ... [Information of the supplier]
BRENDA is the main collection of enzyme functional data available to the scientific community. It is available free of charge for academic, non-profit users via the internet and as an in-house database for commercial users (requests to our distributor Biobase). Today, as the large international genome sequence projects are gaining a great amount of public attention and huge sequence data bases are created it becomes more and more obvious that we are very limited in our ability to access functional data for the gene products - the proteins, in particular for enzymes. Those data are inherently very difficult to collect, interpret and standardize as they are highly distributed among journals from different fields and are often subject to experimental conditions. Nevertheless a systematic collection is essential for our interpretation of the genome information and more so for possible applications of this knowledge in the fields of medicine, agriculture, etc.. Recent progress on enzyme immobilisation, enzyme production, enzyme inhibition, coenzyme regeneration and enzyme engineering has opened up fascinating new fields for the potential application of enzymes in a large range of different areas. The enzymes are classified according to the Enzyme Commission list of enzymes. Some 3500 "different" enzymes are covered. Frequently enzymes with very different properties are included under the same EC number. Although we intend to give a representative overview on the characteristics and variability of each enzyme the Handbook is not a compendium. The reader will have to go to the primary literature for more detailed information. Naturally it is not possible to cover all the numerous literature references for each enzyme (for some enzymes up to 40000) if the data representation is to be concise as is intended. The data collection is being developed into a metabolic network information system with links to Enzyme expression and regulation information. ... [Information of the supplier]
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on ‘small’ chemical compounds. The term ‘molecular entity’ refers to any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer, etc., identifiable as a separately distinguishable entity. The molecular entities in question are either products of nature or synthetic products used to intervene in the processes of living organisms. ChEBI encompasses an ontological classification, whereby the relationships between molecular entities or classes of entities and their parents and/or children are specified. ... [Information of the supplier]
InterPro is a database of protein families, domains and functional sites in which identifiable features found in known proteins can be applied to unknown protein sequences. [Information of the supplier]