EMAGE is a database of in situ gene expression data in the mouse embryo and an accompanying suite of tools to search and analyse the data. mRNA in situ hybridisation, protein immunohistochemistry and transgenic reporter data is included. These are sourced from the community and our curators take this data and describe it in a standardised way that allows data query and exchange. The description includes a text-based component but the unique aspect of EMAGE is its spatial annotation focus. It is the mission at EMAGE: a) To provide a focal point for biomedical and clinical researchers to access mouse embryo in situ gene expression data sourced from the community, b) To offer high-quality curation and annotation of this data in the spatio-temporal and anatomical framework of the EMAP Digital Atlas, c) To generate and offer methods for analysis of this data and d)To provide EMAGE in the broader context of other bioinformatics resources to generate a tool for understanding the genetic control of mouse development. ... [Information of the supplier]
Grid computing is regarded as one of the critical success factors in biomedical Research. The joint project MediGRID unifies well known research institutes in the area of medicine, biomedical informatics and life sciences into a consortium. Numerous associated partners from industry, healthcare and research facilities ensure a broad representation of these communities. The main goal of MediGRID is the Development of a Grid middleware integration platform enabling eScience services for biomedical life science. Therefore the consortium allocated the tasks in different modules. The four methodological modules (middleware, ontology, resource fusion and eScience) plan to incrementally develop and provide a Grid infrastructure while taking into account the need of the biomedical users. The user communities are represented in three research modules for biomedical informatics, image processing and clinical research. ... [Information of the supplier]
Ascertaining when and where genes are expressed is of crucial importance in order to understand the physiological role of a given gene/protein and the interactions between them. In addition, the normal expression patterns can then be compared to those observed in a variety of pathological conditions to identify pathological hallmarks of gene expression. The EURExpress, an integrated project funded by the EU under the VI Framework proposes a transcriptome-wide acquisition of expression patterns chiefly by means of in situ hybridization (ISH) with non-radioactive probes and will use this data to establish a web-linked, interactive digital transcriptome atlas of embryonic mouse. The final goal of the project is to create the expression data of > 20,000 genes by RNA in situ hybridization on sagittal sections from E14.5 wild type murine embryos. This data will result in a detailed description (at a cellular level) of gene expression patterns in the developing mouse. The “transcriptome atlas” will be generated using a newly developed automated RNA in situ hybridization system. Automated scanning microscopes will collect image data, which will be electronically sent out in a digital format for annotation. The latter will be performed using a web-based “virtual” microscope and be entered in a hierarchical database specifically designed to hold large amounts of image data and display them in a user-friendly format. For a subset of genes, mainly those directly involved in human diseases, expression data will also be generated by using human and murine tissue arrays. This will offer the opportunity to compare human and mouse expression patterns in adult tissues. This project builds on a strong European concentration of skills in gene expression analysis and mouse genomics and integrates European skills, efforts, resources and information in the field of systematic gene expression analysis. All expression data generated by EURExpress will be made readily available to the scientific community via the EURExpress web-linked database, considerably advancing our knowledge of gene function and having a significant impact on the identification of gene expression markers of disease processes. ... [Information of the supplier]
In September, 2001, the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) convened a working group of its National Advisory Council to develop a strategic plan for Stem Cells and Developmental Biology. The working group made several recommendations, with the overall goals of providing new strategies for repairing or replacing damaged organs and generating new insights into pathologic processes underlying developmental defects and disease. There is the need for a more thorough understanding of organogenesis so that tissue degeneration and congenital malformations might be prevented and treated. The goal of GUDMAP is a fundamental description of the developing kidney and GU tract. The panel recommended that the following three objectives be combined to form the GUDMAP. a) High throughput in situ hybridization analyses to define the expression pattern of genes expressed in the developing kidney and GU tract, b) High resolution gene expression analyses to define gene expression during developmental time, the overlap in gene expression patterns, and the correlation between boundaries of gene expression and boundaries of anatomic or functional domains and c) Development of a database to house and annotate the above data and to provide rapid access of this data to the entire research community. Microarray analyses and the generation of murine strains with genetic markers are also goals of GUDMAP which serve to bolster the overall aim of defining molecular and cellular anatomy through developmental time. ... [Information of the supplier, modified]
Earthworms are essential to the life and health of the planet's soils, and thus to the life and health of terrestrial ecosystems. Charles Darwin and others have shown that earthworms both make soil, and ensure its fertility. Lumbricus rubellus is a common earthworm, found in many temperate ecosystems, used as a model species by researchers investigating the biology and ecology of the soil, and the effects of pollutants and other chemicals on soil organisms. This website is the home of our efforts to better understand how Lumbricus rubellus and other soil animals "make their living". We are sequencing the genome of Lumbricus rubellus. This will be the first oligochaete annelid genome to be sequenced. The genome sequence will reveal the 'parts list' for this important species, and help us to put together maps of how the worm grows, eats, and reproduces, and how it resists exposures to potentially toxic soil contamination. To do this we are using the resources, instrumentation and expertise of the GenePool, the University of Edinburgh Genomics Facility. The genome sequencing project builds on the successful Lumbricus rubellus Expressed Sequence Tag (EST) transcriptome project. ESTs are a way of sampling the expressed genes of a species, and we, as part of The EcoWorm Consortium gained funding from the UK Natural Environment Research Council (NERC) generate of over 20,000 ESTs. Using a combination of informatics tools these sequences have been analysed and used to build a relational sequence database - LumbriBASE - that can be queried by both sequence similarity and annotation. We have added ESTs from additional annelid species to LumbriBASE to make cross-comparison between species easier. ... [Information of the supplier]
The Barcoding Fauna Bavarica project is an All Species DNA barcoding campaign of the Zoologische Staatssammlung in Munich (ZSM) and the Canadian Centre for DNA Barcoding (CCDB). It represents a major component of Germany's contribution to the International Barcode of Life Project. Core funding comes from the Bavarian State Ministry of Science, Research, and the Arts, and from Genome Canada through the Ontario Genomics Institute. (Stefan Schmidt, unter https://www.youtube.com/watch?v=KOQEYZRrB-s). ... [Miscellaneous as indicated]
With nearly 150,000 described species, flies (the insect order Diptera), are among the most diverse groups of living organisms on the planet. This diversity transcends simple species numbers and is demonstrated in the great breadth of morphological, ecological, and behavioral variation found in the group. Flies have a deep evolutionary history that extends back to the Permian Period, over 250 million years ago. The FLYTREE project is an international research collaboration funded by the US National Science Foundation, to elaborate and discover the details of fly relationships and diversity with the ultimate goal of providing a newly resolved phylogeny for this major branch of the Tree of Life. ... [Information of the supplier]
This private web site is devoted to asiloid flies (Asiloidea, Orthorrapha, Diptera) of the families Apioceridae (flower-loving flies) & Mydidae (mydas flies). Apioceridae (138 species) only occur in Argentina, Australia, Chile, western North America, and South Africa whereas Mydidae (463 species) are distributed worldwide. The web site supplies a bibliography and catalogues of both taxa and presents the aims and recent publications of research project on asiloid flies’ phylogeny, taxonomy, and biogeography. ... [Editorial staff vifabio]
The hoverflies (Diptera, Syrphidae) are a family of attractive and familiar flies that we all see visiting flowers. Gardeners welcome them because many of the black-and-yellow striped species have larvae which prey on greenfly and bacause of their important role in pollination. The National Recording Scheme, launched in 1976, aims to collate information about their ecology and distribution. On this web site you can find: Information about each of the species, maps of species distributions in Great Britain, an up-to-date checklist of British species and forums for discussion of topics related to these fascinating insects. ... [Information of the supplier]
Weltweit gibt es ca. 3500 Stechmückenarten. Allein in Deutschland sind bisher 49 Arten nachgewiesen worden! Diese Zahl verursacht häufig Erstaunen, gehen doch viele Menschen davon aus, dass Stechmücke eben Stechmücke ist. Doch schon bei genauerem Hinschauen lassen sich bereits Unterschiede in Größe und Farbe ausmachen. Da Stechmücken in Deutschland wissenschaftlich lange vernachlässigt wurden, fehlt grundlegendes Wissen über das Vorkommen und die Verbreitung der verschiedenen Arten. Faktoren wie Globalisierung und die so genannte Klimaveränderung begünstigen die Einschleppung und Ansiedlung nicht-einheimischer Mückenarten. Daher sind Fragen wie: "Welche Stechmückenarten kommen aktuell in Deutschland vor?", "Wie verteilen sich diese geografisch?" und "Gibt es Veränderungen hinsichtlich ihres jahreszeitlichen Auftretens?" von besonderem Interesse. Einige Stechmücken und andere blutsaugende Insekten sind in der Lage, Krankheitserreger zu übertragen. Auch in Europa kam es vor wenigen Jahren zu Ausbrüchen von Insekten-assoziierten Krankheiten, so z.B. der Blauzungenkrankheit der Wiederkäuer in ganz Mitteleuropa (Gnitzen als Virusüberträger) oder des Chikungunya-Fiebers des Menschen in Italien (Stechmücken als Virusüberträger). Beide Ereignisse zeigen, dass die grundlegende Forschung an blutsaugenden Insekten, und damit auch an Stechmücken, sehr aktuell und wichtig ist. Es besteht derzeit kein Grund zur Beunruhigung! In Deutschland wurden seit der Ausrottung der Malaria im letzten Jahrhundert keine Fälle von Krankheiten diagnostiziert, deren Erreger hierzulande durch Stechmücken auf den Menschen übertragen worden waren. In wärmeren Ländern ist allerdings schon seit Längerem eine Zunahme solcher Fälle festzustellen, und auch die Ausbreitung von Stechmückenarten, die effiziente Überträger sind, wird beobachtet. Wir fangen und erforschen die einheimischen Stechmückenarten im Auftrag des Robert-Koch-Institutes (RKI) sowie des Bundesministeriums für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV). Unter anderem stellen wir dazu deutschlandweit Fallen auf, gehen aber ebenso eigenhändig auf die Jagd. Da wir daran interessiert sind, von möglichst vielen Standorten in Deutschland Mücken zu erhalten, RUFEN WIR ZUR MÜCKENJAGD AUF. Mit Ihrer Mithilfe können wir das Ergebnis unserer Forschung an Stechmücken noch verbessern. Zum Mückenjäger sind es jetzt nur noch ein paar Schritte. Wenn Sie eine Mückenjägerin oder ein Mückenjäger werden wollen, können Sie hier nachlesen, wie Sie das anstellen. ... [Information des Anbieters]