Sequencing of the human genome has opened the way and provided the impetus for building a comprehensive picture of a mammalian cell. Significant efforts are underway in the fields of genomics and proteomics to identify all genes and proteins in a given organism. The goal is a complete map of the genes, gene products and their interaction networks in a functioning cell. The next step in establishing a comprehensive picture of a cell will be to tie the cell's metabolome into the rapidly developing genomic and proteomic maps. A cell's metabolome, however, is such an enormous and complex entity that characterizing it can only be approached in sections. This consortium is now proposing to focus on the lipid section of the metabolome by developing an integrated metabolomic system capable of characterizing the global changes in lipid metabolites ("lipidomics"). Our consortium has developed a Lipid Metabolites and Pathways Strategy, termed LIPID MAPS, that applies a global integrated approach to the study of lipidomics. ... [Information of the supplier]
The word "aging" encompasses a range of physiological changes in humans, human tissues, and constituent cells. Alterations in metabolism, whether at the level of small molecules, protein homeostasis, signaling patterns, or intertissue communication, underpin many of the processes that ultimately decline or shift during aging. The recent wealth of information on how perturbation of metabolic factors can accelerate or impair aging processes makes this an exciting time to convene and consider the new biology being uncovered, its potential impact on human health, and the implications for the coming age of precision medicine. This meeting brings together scientists who have interests in aging and metabolism to explore the growing intersection between these fields and to discuss key questions in this area for human health and disease. Leaders in the field will share results from cellular research, investigations in model organisms, and studies with translational impact rooted in mammalian systems. ... [Editorial staff vifabio]
The field of immunometabolism has thrived over the last decade, revealing not only the major roles played by immune cells in metabolic homeostasis but also the impact of metabolic pathways on immune cell function. As new discoveries continue to reveal the intricate links between immunology and metabolism, a key question arises: will our accumulated knowledge on immunometabolic deregulations translate into novel therapies for human diseases? During this Cell Symposium, you will hear about the latest advances in immunometabolism from physician-scientists, basic researchers and industry leaders. We will discuss how local and systemic metabolism are integrated at the cellular level to regulate immune cell function and we will focus on how novel insights into immunometabolism can be harnessed to advance and/or bolster therapeutic interventions in metabolic diseases, inflammation, autoimmunity, and cancer. ... [Information of the supplier]
This meeting brings together scientists who have interests in aging, metabolism, and immunology to explore the growing intersection between these fields and to discuss key questions and important areas of future investigation. Our aim is to spur the progress of efforts to elucidate the mechanisms underlying the aging process, so as to inform current approaches of disease treatment and prevention, and to provide an improved understanding of healthy aging. ... [Information of the supplier]
GeneCards® is an integrated database of human genes that includes automatically-mined genomic, proteomic and transcriptomic information, as well as orthologies, disease relationships, SNPs, gene expression, gene function, and service links for ordering assays and antibodies. [Information of the supplier]
The HCV database group strives to present HCV-associated genetic and immunologic data in a userfriendly way, by providing access to the central database via web-accessible search interfaces and supplying a number of analysis tools. (...) The HCV search interface allows you to find and download sequences on the basis of a number of criteria. (...) You can either download all sequences (as nucleotides or amino acid sequences) that meet your criteria, or you can limit your set to a specific gene or region by selecting that genomic region on the search interface. (...) ... [Information of the supplier, modified]
Influenza Virus Resource presents data obtained from the NIAID Influenza Genome Sequencing Project as well as from GenBank, combined with tools for flu sequence analysis and annotation. In addition, it provides links to other resources that contain flu sequences, publications and general information about flu viruses. [Information of the supplier]
The HCV database group strives to present HCV-associated genetic and immunologic data in a userfriendly way, by providing access to the central database via web-accessible search interfaces and supplying a number of analysis tools. (...) The HCV search interface allows you to find and download sequences on the basis of a number of criteria. (...) You can either download all sequences (as nucleotides or amino acid sequences) that meet your criteria, or you can limit your set to a specific gene or region by selecting that genomic region on the search interface. (...) ... [Information of the supplier, modified]
Ein internationales Forschungskonsortium wurde gebildet, um das bislang detaillierteste und medizinisch nützlichste Abbild der genetischen Variabilität beim Menschen zu erstellen. Das "1000 Genomes Project" strebt an, das komplette Erbgut von mindestens 1000 Menschen aus allen Teilen der Welt zu sequenzieren. Die maßgeblichen Unterstützer des Projektes sind das Wellcome Trust Sanger Institute in Hinxton, England, das Beijing Genomics Institute Shenzhen in China und das National Human Genome Research Institute (NHGRI), Teil der National Institutes of Health (NIH) der USA. Unter Rückgriff auf die Fachkompetenz von multidisziplinären Forscherteams wird das "1000 Genomes Project" eine neue Karte des menschlichen Genoms erstellen, die die biomedizinisch relevante Variabilität der DNA in einer vorher nicht denkbaren Genauigkeit darstellt. Wie bei anderen Standards setzenden Projekten zum menschlichen Genom werden auch die Daten aus dem "1000 Genomes Project" durch frei zugängliche Datenbanken der weltweiten wissenschaftlichen Gemeinde zur Verfügung gestellt. ... [Information des Anbieters, übersetzt]
HuGE Literature Finder ist eine Suchmaschine für Literatur über genetische Zusammenhänge und zahlreiche weitere Aspekte von menschlichem Genom und Epidemiologie. Es kann gezielt nach Krankheiten, Umweltfaktoren, Genen, Autorennamen usw. gesucht werden; die Ergebnisse können auf verschiedene Weise gefiltert werden. Die gefundenen Artikellisten enthalten Weiterleitungen zu PubMed, um die dortigen Funktionalitäten einschließlich des Imports in Literaturverwaltungsprogramme nutzen zu können. ... [Information des Anbieters, übersetzt und verändert]
