Planarians are free-living (non-parasitic) freshwater organisms possessing derivatives of all three germ layers (i.e., ectoderm, mesoderm and endoderm). These animals are renowned for their developmental plasticity and have attracted the attention of generations of biologists (http://planaria.neuro.utah.edu). Among all flatworm species studied thus far, the planarian Schmidtea mediterranea is rapidly emerging as a key model organism for the study of regeneration, tissue homeostasis and stem cell biology. The Schmidtea mediterranea Genome Database (SmedGD) is a GMOD compliant database that integrates in a single web-accessible portal all available data associated with the planarian genome, including predicted and annotated genes, ESTs, protein homologies, gene expression patterns and RNAi phenotypes. ... [Information of the supplier]
Wissensschau.de behandelt aus der Sicht eines in der Praxis tätigen Biochemikers vor allem das Thema Stammzellen. Die verschiedenen Aspekte der Biologie und der medizinischen Verwendung von menschlichen Stammzellen einschließlich ethischer Fragen werden in allgemein verständlicher Sprache erläutert. [Redaktion vifabio]
The potential of a pesticide or biocide to cause adverse effects in the developing embryo or fetus is an important consideration in any health risk assessment for humans and wildlife. Such information is usually derived from experimental studies in which pregnant laboratory animals are exposed to various concentrations of compounds during critical stages of fetal development. The terms and diagnostic criteria used to describe fetal anomalies need to be consistent from one laboratory to another. Consequently, the DevTox Project has three main objectives: To harmonize the nomenclature used to describe developmental anomalies in laboratory animals, to assist in the visual recognition of developmental anomalies with the aid of photographs, and to provide a historical control database of developmental effects in laboratory animals. ... [Information of the supplier]
A long-standing goal of biology is to map the behavior of all cells during vertebrate embryogenesis. We developed digital scanned laser light sheet fluorescence microscopy and recorded nuclei localization and movement in entire wild-type and mutant zebrafish embryos over the first 24 hours of development. Multiview in vivo imaging at 1.5 billion voxels per minute provides "digital embryos," that is, comprehensive databases of cell positions, divisions, and migratory tracks. ... [Information of the supplier]
AnAge is a curated database of ageing and life history in animals, including extensive longevity records. AnAge was primarily developed for comparative biology studies, in particular studies of longevity and ageing, but can also be useful for ecological and conservation studies and as a reference for zoos and field biologists. To search AnAge please type keywords or phrases relating to the species or common name of the organism you wish to find. Terms at any taxonomic level are acceptable. AnAge is used by many research groups and has been cited in several publications. It was highlighted in Science (307:187), Nature Reviews Genetics (5:1362), and BioTechniques (39:21). ... [Information of the supplier, modified]
EMAGE is a database of in situ gene expression data in the mouse embryo and an accompanying suite of tools to search and analyse the data. mRNA in situ hybridisation, protein immunohistochemistry and transgenic reporter data is included. These are sourced from the community and our curators take this data and describe it in a standardised way that allows data query and exchange. The description includes a text-based component but the unique aspect of EMAGE is its spatial annotation focus. It is the mission at EMAGE: a) To provide a focal point for biomedical and clinical researchers to access mouse embryo in situ gene expression data sourced from the community, b) To offer high-quality curation and annotation of this data in the spatio-temporal and anatomical framework of the EMAP Digital Atlas, c) To generate and offer methods for analysis of this data and d)To provide EMAGE in the broader context of other bioinformatics resources to generate a tool for understanding the genetic control of mouse development. ... [Information of the supplier]
Welcome to GenAge, a manually curated database of genes related to ageing. GenAge is divided into genes related to longevity and/or ageing in model organisms and ageing-related human genes. The section on human ageing-related genes includes the few genes directly related to ageing in humans and the best candidate genes obtained from model organisms. Human genes are thus considerably better annotated and may serve as a starting point for future studies, including genetic association studies, or even for exploiting clinical interventions in human ageing. A list of genes analyzed for their possible association with human longevity, DNA repair genes classified as ageing- or non-ageing-related, and genes commonly differentially expressed during mammalian ageing which were identified based on our ageing microarray meta-analysis, are also available. The schema of GenAge is available online as well as GenAge's statistics. Release notes for the current build are also available. ... [Information of the supplier]
The International Zebrafish Protein Trap Consortium welcomes you to our database. We currently have teams in the United States, Germany, India, Canada, and Singapore implementing gene-break transposons to create expression-tagged, revertible mutations in zebrafish genes. We provide database services on zfishbook for GBT mutagenesis projects in zebrafish regardless of scale to promote shared use of these valuable resources. (...) zfishbook is a real-time database with full and unrestricted access to all information. Registration allows you to save your favorite lines for easy access, request lines from the Mayo Clinic catalog, contribute to line annotation with appropriate credit, and puts you on an optional mailing list for future zfishbook newletters and updates. We welcome participation from any and all of our peer zebrafish colleagues. Therefore please consider registering to help annotate your favorite tissues and expression domains. ... [Information of the supplier, modified]
The newt Notopthalmus viridescens is the master of regeneration. This organism is known for more than 200 years for its exceptional regenerative capabilities. Newts can completely replace lost appendages like limb and tail, lens and retina and parts of the central nervous system. Moreover, after cardiac injury newts can rebuild the functional myocardium with no scar formation. To date only very limited information from public databases is available. Newt-Omics aims to provide a comprehensive platform of expressed genes during tissue regeneration, including extensive annotations, expression data and experimentally verified peptide sequences with yet no homology to other publically available gene sequences. The goal is to obtain a detailed understanding of the molecular processes underlying tissue regeneration in the newt,that may lead to the development of approaches, efficiently stimulating regenerative pathways in mammalians. ... [Information of the supplier]
Most organisms have a defined lifespan, however life of a species continues and evolves via germline from generation to generation. Recent studies show that tissue stem cells share molecular and developmental signatures with the germline and that even fully differentiated, postmitotic cells can be reprogrammed to regain totipotency. This EMBO/EMBL Symposium will go beyond a description of the phenomena involving stem cell behaviour, programming and reprogramming. It will bring together researchers from different disciplines, who will address fundamental questions of totipotency as they relate to evolution, development and tissue specialization. ... [Information of the supplier]
