This page allows you to test an antibody sequence against the Kabat sequence database. Any unusual residues (occurring in < 1% of chains in the database) will be reported to you. This allows the identification of potential cloning artifacts and sequencing errors. The current Kabat database contains 6014 light chains and 7895 heavy chains. ... [Information of the supplier]
CATH is a hierarchical classification of protein domain structures, which clusters proteins at four major levels, Class(C), Architecture(A), Topology(T) and Homologous superfamily (H).Class, derived from secondary structure content, is assigned for more than 90% of protein structures automatically. Architecture, which describes the gross orientation of secondary structures, independent of connectivities, is currently assigned manually. The topology level clusters structures into fold groups according to their topological connections and numbers of secondary structures. The homologous superfamilies cluster proteins with highly similar structures and functions. The assignments of structures to fold groups and homologous superfamilies are made by sequence and structure comparisons. The boundaries and assignments for each protein domain are determined using a combination of automated and manual procedures. These include computational techniques, empirical and statistical evidence, literature review and expert analysis. ... [Information of the supplier]
The Molecular Genetics Explorer is a BioQUEST software simulation that integrates genetics, biochemistry, and molecular biology to study a biological phenomenon. It is designed to show students the connections between these three key disciplines of modern molecular genetics. It is based on "Botstein's Triangle". [Information of the supplier]
BioMagResBank (BMRB) is the publicly-accessible depository for NMR results from peptides, proteins, and nucleic acids recognized by the International Society of Magnetic Resonance and by the IUPAC-IUBMB-IUPAB Inter-Union Task Group on the Standardization of Data Bases of Protein and Nucleic Acid Structures Determined by NMR Spectroscopy. In addition, BMRB provides reference information and maintains a collection of NMR pulse sequences and computer software for biomolecular NMR. Access to data in BMRB is free directly from its web site (URL http://www.bmrb.wisc.edu) and ftp site (ftp.bmrb.wisc.edu) and will remain so as public funding permits. The concept of a biomolecular NMR data bank was developed under a five-year research grant awarded to the University of Wisconsin-Madison from the National Library of Medicine, National Institutes of Health. ... [Information of the supplier]
The aim of this service is to provide an easy way to generate pictures and movies of protein structures, with the concern of integrating the most frequently used concepts of the molecular graphics fields via the software Dino. High definition pictures and movies are produced via the use of the Megapov engine founded on the Persistance of Vision Ray tracer - POV-Ray engine. This rendering engine is coupled with external programs such as stride (secondary structure determination), or msms (molecular surface calculation). This service can produce static images as well as movies illustrating macromolecular "docking", molecular dynamics, NMR model diversity and protein motions ... [Information of the supplier]
Our goal: to understand protein folding, misfolding, and related diseases. Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out these important functions, they assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, in many ways remains a mystery. Moreover, when proteins do not fold correctly (i.e. "misfold"), there can be serious consequences, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, Huntington's, Parkinson's disease, and many Cancers and cancer-related syndromes. You can help by simply running a piece of software. Folding@home is a distributed computing project -- people from throughout the world download and run software to band together to make one of the largest supercomputers in the world. Every computer takes the project closer to our goals. Folding@home uses novel computational methods coupled to distributed computing, to simulate problems millions of times more challenging than previously achieved. We have had several successes. You can read about them on our Science page, on our Awards page, or go directly to our Results page. ... [Information of the supplier, modified]
The primary goal of computational molecular biology, like molecular biology itself, is to understand the meaning of the genomic information and how this information is expressed. We are interested in the problems of predicting biological function of genes and gene products from their primary sequence and structure (sometimes known as functional genomics). We are interested in predicting structure of protein and DNA from its sequence, and understanding how and when genes are expressed. ... [Information of the supplier]
The HUSAR Bioinformatics Lab at the German Cancer Research Center (DKFZ, Heidelberg) provides cutting-edge bioinformatics support and training to the scientist of the (post-) genomic era. This includes the Heidelberg Unix Sequence Analysis Resources (HUSAR), a large collection of essential sequence analysis tools. We provide the most up-to-date databases and software packages. Our main package - HUSAR - offers more than 260 applications for DNA and protein analysis. In addition to the latest, complete version of the GCG package (about 50% of our applications), you can use tools developed by us and by other ranking researchers in the bioinformatics field. We offer more than 200 databases, which are updated as soon as new versions become available. The major databases are updated every night (e.g. EMBL, GenBank) or weekly (Swissprot, Unigene). With HUSAR you can analyse the newest sequence data available. This is essential, as the DNA databases currently double their sizes in less than 9 months. ... [Information of the supplier]
Die Homepage von Ehud Shapiro, einem der führenden Wissenschaftler im Bereich Nanotechnologie und molekulare Automaten, gibt Einblicke in sein Forschungsgebiet und erlaubt Zugriff auf seine zahlreichen Vorträge (Powerpoint, PDF). Vervollständigt wird die Seite durch Links zu Publikationen und publizierten Presseartikeln. [Redaktion vifabio]
The iGEM Registry is a growing collection of genetic parts that can be mixed and matched to build synthetic biology devices and systems. As part of the synthetic biology community's efforts to make biology easier to engineer, it provides a source of genetic parts to iGEM teams and academic labs. [Information of the supplier]
