This page allows you to test an antibody sequence against the Kabat sequence database. Any unusual residues (occurring in < 1% of chains in the database) will be reported to you. This allows the identification of potential cloning artifacts and sequencing errors. The current Kabat database contains 6014 light chains and 7895 heavy chains. ... [Information of the supplier]
CATH is a hierarchical classification of protein domain structures, which clusters proteins at four major levels, Class(C), Architecture(A), Topology(T) and Homologous superfamily (H).Class, derived from secondary structure content, is assigned for more than 90% of protein structures automatically. Architecture, which describes the gross orientation of secondary structures, independent of connectivities, is currently assigned manually. The topology level clusters structures into fold groups according to their topological connections and numbers of secondary structures. The homologous superfamilies cluster proteins with highly similar structures and functions. The assignments of structures to fold groups and homologous superfamilies are made by sequence and structure comparisons. The boundaries and assignments for each protein domain are determined using a combination of automated and manual procedures. These include computational techniques, empirical and statistical evidence, literature review and expert analysis. ... [Information of the supplier]
The Molecular Genetics Explorer is a BioQUEST software simulation that integrates genetics, biochemistry, and molecular biology to study a biological phenomenon. It is designed to show students the connections between these three key disciplines of modern molecular genetics. It is based on "Botstein's Triangle". [Information of the supplier]
The primary goal of computational molecular biology, like molecular biology itself, is to understand the meaning of the genomic information and how this information is expressed. We are interested in the problems of predicting biological function of genes and gene products from their primary sequence and structure (sometimes known as functional genomics). We are interested in predicting structure of protein and DNA from its sequence, and understanding how and when genes are expressed. ... [Information of the supplier]
The HUSAR Bioinformatics Lab at the German Cancer Research Center (DKFZ, Heidelberg) provides cutting-edge bioinformatics support and training to the scientist of the (post-) genomic era. This includes the Heidelberg Unix Sequence Analysis Resources (HUSAR), a large collection of essential sequence analysis tools. We provide the most up-to-date databases and software packages. Our main package - HUSAR - offers more than 260 applications for DNA and protein analysis. In addition to the latest, complete version of the GCG package (about 50% of our applications), you can use tools developed by us and by other ranking researchers in the bioinformatics field. We offer more than 200 databases, which are updated as soon as new versions become available. The major databases are updated every night (e.g. EMBL, GenBank) or weekly (Swissprot, Unigene). With HUSAR you can analyse the newest sequence data available. This is essential, as the DNA databases currently double their sizes in less than 9 months. ... [Information of the supplier]
Die Homepage von Ehud Shapiro, einem der führenden Wissenschaftler im Bereich Nanotechnologie und molekulare Automaten, gibt Einblicke in sein Forschungsgebiet und erlaubt Zugriff auf seine zahlreichen Vorträge (Powerpoint, PDF). Vervollständigt wird die Seite durch Links zu Publikationen und publizierten Presseartikeln. [Redaktion vifabio]
The iGEM Registry is a growing collection of genetic parts that can be mixed and matched to build synthetic biology devices and systems. As part of the synthetic biology community's efforts to make biology easier to engineer, it provides a source of genetic parts to iGEM teams and academic labs. [Information of the supplier]
Ensembl is a joint project between EMBL - European Bioinformatics Institute (EBI) and the Wellcome Trust Sanger Institute (WTSI) to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. The Ensembl project aims to provide: accurate, automatic analysis of genome data, analysis and annotation maintained on the current data, presentation of the analysis to all via the web, distribution of the analysis to other bioinformatics laboratories. Ensembl will concentrate on vertebrate genomes, but other groups have adapted the system for use with plant and fungal genomes. ... [Information of the supplier, modified]
Welcome to DAVID Bioinformatics Resources 2003 – 2009. The Database for Annotation, Visualization and Integrated Discovery (DAVID). DAVID 2008 is the sixth version of our original web-accessible programs. DAVID now provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes. For any given gene list, DAVID tools are able to identify enriched biological themes, particularly GO terms; to discover enriched functional-related gene groups; to search for other functionally related genes; to list interacting proteins; and to link gene-disease associations. ... [Information of the supplier, modified]
GenMAPP is a free computer application designed to visualize gene expression and other genomic data on maps representing biological pathways and groupings of genes. Integrated with GenMAPP are programs to perform a global analysis of gene expression or genomic data in the context of hundreds of pathway MAPPs and thousands of Gene Ontology Terms (MAPPFinder), import lists of genes/proteins to build new MAPPs (MAPPBuilder), and export archives of MAPPs and expression/genomic data to the web. The main features underlying GenMAPP are: 1) Draw pathways with easy to use graphics tools; 2) Color genes on MAPP files based on user-imported genomic data; 3) Query data against MAPPs and the GeneOntology. ... [Information of the supplier]