The Molecular Modeling Database (MMDB) contains 3D macromolecular structures, including proteins and polynucleotides. MMDB contains over 28,000 structures and is linked to the rest of the NCBI databases, including sequences, bibliographic citations, taxonomic classifications, and sequence and structure neighbors. [Information of the supplier]
MPtopo is a curated database of membrane proteins with experimentally validated transmembrane (TM) segments. The database is maintained in SQL form using the MySQL server. It can be searched using MPtopoQuerier, a java applet developed for this purpose. Retrieved sequences can be examined automatically by MPEx, a java-based hydropathy-plot tool. MPtopo currently contains a total of 167 proteins with 1028 TM segments. ... [Information of the supplier, modified]
The Nuclear Protein Database (NPD) is a searchable database of information on proteins that are localised to the nucleus of vertebrate cells. The NPD contains information on >1000 vertebrate proteins (mainly those from mouse and human) that are thought to, or known to, be localised to the cell nucleus. Where known, the sub-nuclear compartment where the proteins have been found are reported. Also stored is information on the amino acid sequence, predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. Biological and molecular functions of the proteins are described using GO terms. Where appropriate, links to other databases are provided. ... [Information of the supplier]
Pfam (Protein families database of alignments and HMMs) klassifiziert Proteinfamilien mit Hilfe von Profilen. Basiert auf Sequenz-Alignments als Ausgangspunkte zur automatischen Erstellung von Hidden Markov Modellen (HMM). [Redaktion vifabio]
PRINTS bietet eine Übersicht für Fingerprints zur Klassifizierung von DNS- und Proteinsequenzen. Die Datenbank enthält Kreuzreferenzen zu Einträgen verwandter Datenbanken mit weiterführenden Informationen, darüber hinaus Freitextinformationen zur Proteinfamilie und zur biologischen Funktion der Fingerprint-Motive. [Redaktion vifabio]
PDB, von einem Non-profit-Konsortium mehrerer US-Forschungsinstitutionen erstellt, ist eine Datenbank für 3-D Strukturdaten von Proteinen und Nukleinsäuren. Die Strukturen biologischer Makromoleküle werden in Beziehung zu Sequenzen, Funktionen und medizinischer Relevanz gesetzt. [Redaktion vifabio]
PubChem contains the chemical structures of small organic molecules and information on their biological activities. PubChem is intended to support the Molecular Libraries and Imaging component of the NIH Roadmap Initiative. PubChem's chemical structure database may be searched on the basis of descriptive terms, chemical properties, and structural similarity. When possible, PubChem's chemical structure records are linked to other NCBI databases. These include the PubMed scientific literature database, for example, and NCBI's protein 3D structure database. PubChem also contains the results of high-throughput biological screening experiments. ... [Information of the supplier]
RTPrimerDB is a public database for primer and probe sequences used in real-time PCR assays employing popular chemistries (SYBR Green I, Taqman, Hybridisation Probes, Molecular Beacon) to prevent time-consuming primer design and experimental optimisation, and to introduce a certain level of uniformity and standardisation among different laboratories. We strongly encourage researchers to submit their validated primer and probe sequence, so that other users can benefit from their expertise. The database can be queried using the official gene name or symbol, Entrez or Ensembl Gene identifier, SNP identifier, or oligonucleotide sequence. Different options make it possible to restrict a query to a particular application (Gene Expression Quantification/Detection, DNA Copy Number Quantification/Detection, SNP Detection, Mutation Analysis, Fusion Gene Quantification/Detection), organism (Human, Mouse, Rat, and 17 others) or detection chemistry. Data submission is allowed after free registration whereby you obtain a login name and password. Currently, 3607 real-time PCR assays for 2214 genes are available, submitted by 848 people. ... [Information of the supplier]
Die Restriction Enzyme Database ist eine Sammlung von Informationen über Restriktionsenzyme, Methylasen, die Mikroorganismen aus denen sie isoliert worden sind, Erkennungssequenzen, Cleavage-Sites, Spezifität der Methylierung, die kommerzielle Verfügbarkeit der Enzyme, sowie Referenzen (sowohl publizierte Literatur als auch unpublizierte Beobachtungen, zurückreichend bis 1952). ... [Information des Anbieters, übersetzt]
Der Malaria-Erreger und verschiedene Aspekte seines Metabolismus’ sind das Thema dieser Site. Viele Informationen zu Genen, Enzymen und Stoffwechselwegen wurden zusammengestellt, die auch nach Enzym- bzw. Proteinnamen und Komponenten durchsuchbar sind. [Redaktion vifabio]