Detailed overview:
Rhea - Annotated reactions database
Title: Rhea - Annotated reactions database
Title abbreviated: Rhea
Creator: Alcántara, Rafael; et al.
Publisher: EBI = European Bioinformatics Institute
Abstract: Rhea is a reaction database, where all reaction participants (reactants and products) are linked to the ChEBI database (Chemical Entities of Biological Interest) which provides detailed information about structure, formula and charge. Rhea provides built-in validations that ensure both elemental and charge balance of the reactions. We have populated the database with the reactions found in the EC list (and in the IntEnz and ENZYME databases), extending it with additional known reactions of biological interest. While the main focus of Rhea is enzyme-catalysed reactions, other biochemical reactions (including those that are often termed "spontaneous") also are included. Rhea is a manually annotated resource and it provides: a)Stable reaction identifiers for each of its reactions. These identifiers are independent of EC numbers but are linked to EC numbers via cross-references; b)Directionality information if the physiological direction of the reaction is known; c)The possibility to link several reactions together to form complex reactions. This feature can also be used to split reactions into partial reactions; d)Extensive cross-references to other resources including enzyme-catalysed and other metabolic reactions, such as the EC list (in IntEnz), KEGG, MetaCyc and UniPathway; e)Chemical substructure and similarity searches on compounds in Rhea, thereby allowing reactions to be found where similar compounds are involved. The database is extensively cross-referenced. Reactions are currently linked to the EC list, KEGG and MetaCyc, and the reactions will be used in the IntEnz database and in all relevant UniProtKB entries. Furthermore, the reactions will also be used in the UniPathway database to generate pathways and metabolic networks. [Information of the supplier]
Subject: General topics of biochemistry (572.3)
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Audience: Experts
Language: English
Format: website; database
Resource type: Factual databases
Access: free
Metadata update date: 2012-12-18
Metadata provider: UBFfm
URL of this vifabio-resource:
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