Detailed overview:
CPLA - Compendium of Protein Lysine Acetylation
Title: CPLA - Compendium of Protein Lysine Acetylation
Title abbreviated: CPLA
Creator: Xue, Yu; et al.
Publisher: Huazhong University of Science and Technology / Department of Systems Biology / Cuckoo Workgroup
Abstract: There are two types of acetylation processes widely occurred in proteins. The first Nα-terminal acetylation is catalyzed a variety of N-terminal acetyltransferases (NATs), which cotranslationally transfer acetyl moieties from acetyl-coenzyme A (Acetyl-CoA) to the α-amino (Nα) group of protein amino-terminal residues. Although Nα-terminal acetylation is rare in prokaryotes, it was estimated that about 85% of eukaryotic proteins are Nα-terminally modified. The second type is Nε-lysine acetylation, which specifically modifies ε-amino group of protein lysine residues. Although Nε-lysine acetylation is less common, it's one of the most important and ubiquitous post-translational modifications conserved in prokaryotes and eukaryotes. Moreover, the acetylation and deacetylation are dynamically and temporally regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. Since the number of known acetylation sites is rapidly increased, it is an urgent topic to collect the experimental data and provide an integrated resource for the community. Recently, several public databases, such as PhosphoSitePlus, HPRD, SysPTM, and dbPTM, have already contained protein acetylation information. In these databases, both of Nα-terminal and Nε-lysine acetylation data were curated, while lysine acetylation sites are usually only a limited part of total sites. So, thousands of lysine acetylation sites in other species still remain to be collected. Currently, the CPLA 1.0 database was updated on March 1st, 2010, containing 3,311 unique protein entries with 7,151 lysine acetylation sites. The online service of CPLA 1.0 was implemented in PHP + MySQL + JavaScript. And the local packages of CPLA 1.0 were developed in JAVA 1.5 (J2SE). The database will be updated routinely as new acetylated lysines are reported. [Information of the supplier, modified]
Subject: Proteins (572.6)
» find similar sources!
Audience: Experts
Language: English
Format: website; database
Resource type: Factual databases
Access: free
Metadata update date: 2013-01-07
Metadata provider: UBFfm
URL of this vifabio-resource:
© Virtuelle Fachbibliothek Biologie (vifabio)
 Print window Close window