|Title:||eQuilibrator: The Biochemical Thermodynamics Calculator|
|Creator:||Weizmann Institute <Rehovot, Israel> / Milo Lab|
|Abstract:||eQuilibrator is a simple web interface designed to enable easy thermodynamic analysis of biochemical systems. eQuilibrator enables free-text search for biochemical compounds and reactions and provides thermodynamic estimates for both in a variety of conditions. Estimation of thermodynamic parameters (ΔrG and ΔfG) elucidates how much energy is required to drive a particular biochemical reaction and in which direction the reaction will flow in particular cellular conditions. Because experimental measurement of the free energy of formation (ΔfG°) of compounds is technically challenging, the vast majority of known metabolites have not been thermodynamically characterized. eQuilibrator uses a well-studied approximation of ΔfG called group contribution, enabling thermodynamic analysis of many biochemical reactions and pathways. Currently, eQuilibrator can provide estimates for many compounds in the KEGG database(about 4500). Individual compounds and enzymes can be searched for by their common names ("water", "glucosamine", "hexokinase"), and reactions can be entered in a simple, free-text format ("ribulose bisphosphate + CO2 + water => 2 3-phosphoglycerate") that eQuilibrator parses automatically. eQuilibrator also allows manipulation of the conditions of a reaction - pH, ionic strength, and reactant and product concentrations - to help explore the thermodynamic landscape of a biochemical reaction. eQuilibrator is a project of the Milo Lab at the Weizmann Institute in Rehovot, Israel. [Information of the supplier]|
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|Resource type:||Discipline based websites|
|Metadata update date:||2014-01-03|
|URL of this vifabio-resource:||http://www.vifabio.de/en/iqfBio/detail/7494|
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