Detailed overview:
Roadmap Epigenomics Project
Title: Roadmap Epigenomics Project
Creator: National Institutes of Health = NIH / Roadmap Epigenomics Mapping Consortium
Abstract: Epigenetics is an emerging frontier of science that involves the study of changes in the regulation of gene activity and expression that are not dependent on gene sequence. For purposes of the Roadmap Epigenomics Project, epigenetics refers to both heritable changes in gene activity and expression (in the progeny of cells or of individuals) and also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable. While epigenetics refers to the study of single genes or sets of genes, epigenomics refers to more global analyses of epigenetic changes across the entire genome. The NIH Roadmap Epigenomics Mapping Consortium was launched with the goal of producing a public resource of human epigenomic data to catalyze basic biology and disease-oriented research. The Consortium leverages experimental pipelines built around next-generation sequencing technologies to map DNA methylation, histone modifications, chromatin accessibility and small RNA transcripts in stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease. The Consortium expects to deliver a collection of normal epigenomes that will provide a framework or reference for comparison and integration within a broad array of future studies. The Consortium also aims to close the gap between data generation and its public dissemination by rapid release of raw sequence data, profiles of epigenomics features and higher-level integrated maps to the scientific community. [Information of the supplier, modified]
Table of contents: Overview / Project Data / Mapping Centers / Protocols & Standards / Publications / News.
Subject: Biochemical genetics (572.8)
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Audience: Intermediate; Experts
Language: English
Format: website
Resource type: Discipline based websites
Access: free
Metadata update date: 2010-11-23
Metadata provider: UBFfm
URL of this vifabio-resource:
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