Detailed overview:
SMART - Simple Modular Architecture Research Tool
Title: SMART - Simple Modular Architecture Research Tool
Title abbreviated: SMART
Creator: Schultz, Jörg; et al.
Publisher: EMBL = European Molecular Biology Laboratory
Abstract: SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures. More than 500 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa. For all the details, please refer to the publications on SMART. You can use SMART in two different modes: normal or genomic. The main difference is in the underlying protein database used. In Normal SMART, the database contains Swiss-Prot, SP-TrEMBL and stable Ensembl proteomes. In Genomic SMART, only the proteomes of completely sequenced genomes are used; Ensembl for metazoans and Swiss-Prot for the rest. The complete list of genomes in Genomic SMART is available here. The protein database in Normal SMART has significant redundancy, even though identical proteins are removed. If you use SMART to explore domain architectures, or want to find exact domain counts in various genomes, consider switching to Genomic mode. The numbers in the domain annotation pages will be more accurate, and there will not be many protein fragments corresponding to the same gene in the architecture query results. Remember you are exploring a limited set of genomes, though. [Information of the supplier]
Subject: Proteins (572.6)
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Audience: Experts
Language: English
Format: website; database
Resource type: Factual databases
Access: free
Metadata update date: 2014-09-29
Metadata provider: UBFfm
URL of this vifabio-resource:
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