The p53 tumor suppressor gene was initially identified as being essential for the DNA damage checkpoint, but it was subsequently found to have a broader function after cellular stress, such as oncogene activation or hypoxia. The p53 protein functions as a tetrameric transcription factor found at very low levels in normal unstressed cells. After stress, different pathways lead to post-translational modification of the protein and its stabilization. p53 database contains 16,000+ entries corresponding to TP53 mutations found in tumors, normal skin, and noncancerous diseases such as rheumatoid arthritis. The database also includes germline mutations found in Li-Fraumeni syndrome (LFS) and LFS-like syndrome. [Information of the supplier, modified]
Medicine and health (610)
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|Resource type:||Factual databases|
|Metadata update date:||2012-05-11|
|URL of this vifabio-resource:||http://www.vifabio.de/en/iqfBio/detail/338|
|© Virtuelle Fachbibliothek Biologie (vifabio)|