Detailed overview:
p53 Database
p53 Database
| Title: | p53 Database |
| Identifier: | http://p53.free.fr/ |
| Creator: | Soussi, Thierry |
| Contributor: | et al. |
| Abstract: |
The p53 tumor suppressor gene was initially identified as being essential for the DNA damage checkpoint, but it was subsequently found to have a broader function after cellular stress, such as oncogene activation or hypoxia. The p53 protein functions as a tetrameric transcription factor found at very low levels in normal unstressed cells. After stress, different pathways lead to post-translational modification of the protein and its stabilization. p53 database contains 16,000+ entries corresponding to TP53 mutations found in tumors, normal skin, and noncancerous diseases such as rheumatoid arthritis. The database also includes germline mutations found in Li-Fraumeni syndrome (LFS) and LFS-like syndrome. [Information of the supplier, modified] Sequence Databases |
| Subject: |
Proteins (572.6); Mammals (599); Medicine and health (610) » find similar sources! |
| Audience: | Experts |
| Language: | English |
| Format: | website; database |
| Resource type: | Factual databases |
| Access: | free |
| Metadata update date: | 2012-05-11 |
| Metadata provider: |
 |
| URL of this vifabio-resource: | http://www.vifabio.de/en/iqfBio/detail/338 |
| © Virtuelle Fachbibliothek Biologie (vifabio) | |