Detailed overview:
Mouse Proteome Project - [Protein-Organelle-Database]
Mouse Proteome Project - [Protein-Organelle-Database]
| Title: | Mouse Proteome Project - [Protein-Organelle-Database] |
| Title abbreviated: | Mouse Proteome Project |
| Identifier: | http://tap.med.utoronto.ca/~mts/ |
| Creator: | Ignatchenko, Alexandr; Chung, Clement |
| Abstract: | Organs and organelles represent core biological systems in mammals, but the diversity in protein composition remains unclear. Here, we combine subcellular fractionation with exhaustive tandem mass spectrometry-based shotgun sequencing to examine the protein content of four major organellar compartments (cytosol, membranes [microsomes], mitochondria and nuclei) in six organs (brain, heart, kidney, liver, lung and placenta) of the laboratory mouse, Mus musculus. Using rigorous statistical filtering and machine-learning methods, the subcellular localization of 3274 of the 4768 proteins identified was determined with high-confidence, including 1503 previously uncharacterized factors, while tissue-selectivity was evaluated by comparison to previously reported mRNA expression patterns. This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal. [Information of the supplier] |
| Subject: |
Proteins (572.6); Mammals (599) » find similar sources! |
| Audience: | Intermediate; Experts |
| Language: | English |
| Format: | website; database |
| Resource type: | Factual databases |
| Access: | free |
| Metadata update date: | 2009-02-24 |
| Metadata provider: |
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| URL of this vifabio-resource: | http://www.vifabio.de/en/iqfBio/detail/1614 |
| © Virtuelle Fachbibliothek Biologie (vifabio) | |