Detailed overview:
LOCATE - Subcellular localization database
LOCATE - Subcellular localization database
| Title: | LOCATE - Subcellular localization database |
| Title abbreviated: | LOCATE |
| Title alternative: | Mammalian Protein Localization Database |
| Identifier: | http://locate.imb.uq.edu.au/ |
| Creator: | University of Queensland <Brisbane> / Institute of Molecular Bioscience; Australian Research Council = ARC / Centre in Bioinformatics |
| Abstract: | The membrane organization and subcellular location of a protein can provide information about its functional role. Historically, these data have been difficult to produce on a large scale for higher eukaryotic organisms. However, recent advances in membrane organization prediction methods and high-throughput subcellular localization assays have made it possible to generate these datasets. LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were determined by a high-throughput, immunofluorescence-based assay and by manually reviewing over 1700 peer-reviewed publications. The results of the MemO pipeline and the subcellular localization methods are stored in the database with supporting information including a graphical depiction of the membrane organization juxtaposed with InterPro-predicted features and links to several external databases. The database is searchable by subcellular location, protein class, descriptive keyword, and sequence similarity. The data are retrievable in human- and machine-readable formats and in batch. [Information of the supplier] |
| Subject: |
Cell biology (571.6); Proteins (572.6); Miscellaneous orders of Eutheria (placental mammals) (599.3) » find similar sources! |
| Audience: | Intermediate; Experts |
| Language: | English |
| Format: | website; database |
| Resource type: | Factual databases |
| Access: | free |
| Metadata update date: | 2011-01-04 |
| Metadata provider: |
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| URL of this vifabio-resource: | http://www.vifabio.de/en/iqfBio/detail/1599 |
| © Virtuelle Fachbibliothek Biologie (vifabio) | |