This dataset contains 99 genes and comes from Catalina Betancur's review published in Brain Research in 2011 (Betancur, 2011). Different genetic and genomic disorders in which ASDs have been described as one of the possible manifestations were collected. Genes, CNVs and linkage regions associated with autism were searched from literature and curated. Six categories of literatures were included in our collection: genome-wide association studies, expression profiling, genome-wide CNV studies, linkage analysis, low-scale genetic association studies and other low-scale gene studies. Representative meta-data about key clinical and demographic characteristics was collected. ... [Information of the supplier]
The Avian Knowledge Network (AKN) is an international organization of government and non-government institutions focused on understanding the patterns and dynamics of bird populations across the Western Hemisphere. The goal is to educate the public on the dynamics of bird populations, provide interactive decision-making tools for land managers, make available a data resource for scientific research, and advance new exploratory analysis techniques to study bird populations. Additionally, the AKN has gathered over 1300 environmental, climate, and human demographic variables that are linked to all AKN bird observation locations. The AKN is organizing observation-based bird monitoring in three fundamental ways. First, we are developing new ways to discover these data by displaying metadata in the bird monitoring data registry (BMDR). Second, we are expanding existing data schemas to organize these data through the bird monitoring data exchange (BMDE). Third, we are building the technical infrastructure to allow access to these data through a federated data grid environment. ... [Information of the supplier, modified]
BioCatalogue will provide a curated and comprehensive catalogue of biological web services, thereby enabling users (people and programs) to discover and use these services easily. It also aims to provide a platform with several (standardized) interfaces and a suite of tools for registration of services by the community of users as well as empower the community to extend and enhance the system. BioCatalogue will provide a centralized biological web services market place which will be accessible to the world as it will be searchable and indexable to search engines. BioCatalogue will provide a quality of service standard for biological web services thereby enabling services to be classified and checked for availability, reliability and other quality measures. BioCatalogue is a BBSRC funded project and has been running since 1st June 2008. The project is a joint venture between the EMBL-EBI (led by Rodrigo Lopez) and the myGrid project at the University of Manchester (led by Carole Goble). ... [Information of the supplier]
A functional prototype of the Biodiversity-Exploratory Information System (BExIS) has been established by Dr. Jens Nieschulze and colleages (group leader Prof. Dr. Ernst-Detlef Schulze), MPI Biogeochemistry Jena. The system is heavily used within the project "Biodiversity Exploratories", mostly by the resources and map functionality but increasingly also by its data management capabilities. ... [Information of the supplier]
BioPop is (1) a database of ecological and life-history traits of the plant species of the Central European Flora, and (2) an expert system based on this database and designed to support decision-making in landscape planning and nature conservation. You are able to test a prototype of BioPop now. Note that functions are limited. ... [Information of the supplier]
Ascertaining when and where genes are expressed is of crucial importance in order to understand the physiological role of a given gene/protein and the interactions between them. In addition, the normal expression patterns can then be compared to those observed in a variety of pathological conditions to identify pathological hallmarks of gene expression. The EURExpress, an integrated project funded by the EU under the VI Framework proposes a transcriptome-wide acquisition of expression patterns chiefly by means of in situ hybridization (ISH) with non-radioactive probes and will use this data to establish a web-linked, interactive digital transcriptome atlas of embryonic mouse. The final goal of the project is to create the expression data of > 20,000 genes by RNA in situ hybridization on sagittal sections from E14.5 wild type murine embryos. This data will result in a detailed description (at a cellular level) of gene expression patterns in the developing mouse. The “transcriptome atlas” will be generated using a newly developed automated RNA in situ hybridization system. Automated scanning microscopes will collect image data, which will be electronically sent out in a digital format for annotation. The latter will be performed using a web-based “virtual” microscope and be entered in a hierarchical database specifically designed to hold large amounts of image data and display them in a user-friendly format. For a subset of genes, mainly those directly involved in human diseases, expression data will also be generated by using human and murine tissue arrays. This will offer the opportunity to compare human and mouse expression patterns in adult tissues. This project builds on a strong European concentration of skills in gene expression analysis and mouse genomics and integrates European skills, efforts, resources and information in the field of systematic gene expression analysis. All expression data generated by EURExpress will be made readily available to the scientific community via the EURExpress web-linked database, considerably advancing our knowledge of gene function and having a significant impact on the identification of gene expression markers of disease processes. ... [Information of the supplier]
Genes to Cognition (G2C) is a neuroscience research programme with the dual aim of discovering fundamental biological principles and important insights into brain disease. G2C is an international collaborative program initiated by Dr. Seth Grant and supported by the Wellcome Trust following the discovery that multiprotein complexes formed by intracellular proteins and neurotransmitter receptors were important for neuronal plasticity and behaviour. Multiprotein complexes are involved with dozens of brain diseases, control multiple types of behaviours and are involved with the responses to drug treatments of mental disorders. Evolutionary studies show ancient forms of the complexes evolved over a billion years in single cell animals and may represent the origin of the brain. The long term goal is to understand the molecular basis of the extraordinarily complex brain of humans, how this complexity evolved, what it confers on behaviour and why brain evolution made us susceptible to mental illness. The G2C project has a unique database called G2Cdb that houses data resources from the research program and G2C has a very interesting educational program called G2COnline. ... [Information of the supplier, modified]
In September, 2001, the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) convened a working group of its National Advisory Council to develop a strategic plan for Stem Cells and Developmental Biology. The working group made several recommendations, with the overall goals of providing new strategies for repairing or replacing damaged organs and generating new insights into pathologic processes underlying developmental defects and disease. There is the need for a more thorough understanding of organogenesis so that tissue degeneration and congenital malformations might be prevented and treated. The goal of GUDMAP is a fundamental description of the developing kidney and GU tract. The panel recommended that the following three objectives be combined to form the GUDMAP. a) High throughput in situ hybridization analyses to define the expression pattern of genes expressed in the developing kidney and GU tract, b) High resolution gene expression analyses to define gene expression during developmental time, the overlap in gene expression patterns, and the correlation between boundaries of gene expression and boundaries of anatomic or functional domains and c) Development of a database to house and annotate the above data and to provide rapid access of this data to the entire research community. Microarray analyses and the generation of murine strains with genetic markers are also goals of GUDMAP which serve to bolster the overall aim of defining molecular and cellular anatomy through developmental time. ... [Information of the supplier, modified]
The goal of creating the Human Oral Microbiome Database (HOMD) is to provide the scientific community with comprehensive information on the approximately 600 prokaryote species that are present in the human oral cavity. The majority of these species are uncultivated and unnamed, recognized primarily by their 16S rRNA sequences. The HOMD presents a provisional naming scheme for the currently unnamed species so that strain, clone, and probe data from any laboratory can be directly linked to a stably named reference entity. The HOMD links sequence data with phenotypic, phylogenetic, clinical, and bibliographic information. Full and partial oral bacterial genome sequences determined as part of this project and the Human Microbiome Project, are being added to the HOMD as they become available. HOMD offers easy to used tools for viewing all publically available oral bacterial genomes. ... [Information of the supplier]
MassBank is the first public repository of mass spectral data for sharing them among scientific research community. MassBank data are useful for the chemical identification and structure elucidation of chemical compounds detected by mass spectrometry. This website counts with the following features: a) distributed database, b) high precision and accurate mass spectra of primary metabolites and secondary metabolites, c) mass spectral search by exact m/z and browsing interface and d) search for merged spectra. A merged spectrum is generated from spectra of the identical compound measured in different CID conditions. The MassBank Record for each merged spectrum includes information of its original spectra. ... [Information of the supplier, modified]
