Welcome to GenAge, a manually curated database of genes related to ageing. GenAge is divided into genes related to longevity and/or ageing in model organisms and ageing-related human genes. The section on human ageing-related genes includes the few genes directly related to ageing in humans and the best candidate genes obtained from model organisms. Human genes are thus considerably better annotated and may serve as a starting point for future studies, including genetic association studies, or even for exploiting clinical interventions in human ageing. A list of genes analyzed for their possible association with human longevity, DNA repair genes classified as ageing- or non-ageing-related, and genes commonly differentially expressed during mammalian ageing which were identified based on our ageing microarray meta-analysis, are also available. The schema of GenAge is available online as well as GenAge's statistics. Release notes for the current build are also available. ... [Information of the supplier]
The internet Primate Aging Database (iPAD) is a multi-centered, relational database of biological variables in aging, captive nonhuman primates. Through joint initiative of the National Institute on Aging (intramural and extramural programs), National Center for Research Resources (NCRR), and the National Primate Research Center at the University of Wisconsin-Madison (WNPRC), we have organized a database to study biomarkers of aging in nonhuman primates. iPAD also provides an invaluable veterinary and clinical resource, and can generate normative data for numbers of animals across research settings. iPAD now contains over 400,000 data points for body weight, blood chemistry and hematology, for healthy, non-experimental subjects across time. ... [Information of the supplier]
The potential of a pesticide or biocide to cause adverse effects in the developing embryo or fetus is an important consideration in any health risk assessment for humans and wildlife. Such information is usually derived from experimental studies in which pregnant laboratory animals are exposed to various concentrations of compounds during critical stages of fetal development. The terms and diagnostic criteria used to describe fetal anomalies need to be consistent from one laboratory to another. Consequently, the DevTox Project has three main objectives: To harmonize the nomenclature used to describe developmental anomalies in laboratory animals, to assist in the visual recognition of developmental anomalies with the aid of photographs, and to provide a historical control database of developmental effects in laboratory animals. ... [Information of the supplier]
Driven by a need to improve our understanding of molecular processes that are common and unique across cancer stem cells (CSCs), we have developed the Stem Cell Discovery Engine (SCDE)—an online database of curated CSC experiments coupled to the Galaxy analytical framework. The SCDE allows users to consistently describe, share and compare CSC data at the gene and pathway level. Our initial focus has been on carefully curating tissue and cancer stem cell-related experiments from blood, intestine and brain to create a high quality resource containing 53 public studies and 1098 assays. The experimental information is captured and stored in the multi-omics Investigation/Study/Assay (ISA-Tab) format and can be queried in the data repository. (Taken from: Shannan J. Ho Sui, Kimberly Begley, Dorothy Reilly, Brad Chapman, Ray McGovern, Philippe Rocca-Sera, Eamonn Maguire, Gabriel M. Altschuler, Terah A. A. Hansen, Ramakrishna Sompallae, Andrei Krivtsov, Ramesh A. Shivdasani, Scott A. Armstrong, Aedín C. Culhane, Mick Correll, Susanna-Assunta Sansone, Oliver Hofmann, and Winston Hide: The Stem Cell Discovery Engine: an integrated repository and analysis system for cancer stem cell comparisons. In: Nucl. Acids Res. (2012) 40(D1): D984-D991) ... [Miscellaneous as indicated]
