Over 5 million bird specimens are housed in North American collections, documenting the composition, distribution, ecology, and systematics of the world's estimated 10,000-16,000 bird species. Millions of additional observational records are held in diverse data sets. ORNIS addresses the urgent call for increased access to these data in an open and collaborative manner, and involves development of a suite of online software tools for data analysis and error-checking. This project, funded by the National Science Foundation, expands on existing infrastructure developed for distributed mammal (MaNIS), amphibian and reptile (HerpNet), and fish (FishNet) databases. ... [Information of the supplier]
The p53 tumor suppressor gene was initially identified as being essential for the DNA damage checkpoint, but it was subsequently found to have a broader function after cellular stress, such as oncogene activation or hypoxia. The p53 protein functions as a tetrameric transcription factor found at very low levels in normal unstressed cells. After stress, different pathways lead to post-translational modification of the protein and its stabilization. p53 database contains 16,000+ entries corresponding to TP53 mutations found in tumors, normal skin, and noncancerous diseases such as rheumatoid arthritis. The database also includes germline mutations found in Li-Fraumeni syndrome (LFS) and LFS-like syndrome. ... [Information of the supplier, modified]
The Mammal Species of the World (MSW) is a database of mammalian taxonomy. It is hoped that this database on the World Wide Web can be used as a convenient on-line reference for identifying or verifying recognized scientific names and for taxonomic research. The names are organized in a hierarchy that includes Order, Family, Subfamily, Genus and Species. ... [Information of the supplier]
Organs and organelles represent core biological systems in mammals, but the diversity in protein composition remains unclear. Here, we combine subcellular fractionation with exhaustive tandem mass spectrometry-based shotgun sequencing to examine the protein content of four major organellar compartments (cytosol, membranes [microsomes], mitochondria and nuclei) in six organs (brain, heart, kidney, liver, lung and placenta) of the laboratory mouse, Mus musculus. Using rigorous statistical filtering and machine-learning methods, the subcellular localization of 3274 of the 4768 proteins identified was determined with high-confidence, including 1503 previously uncharacterized factors, while tissue-selectivity was evaluated by comparison to previously reported mRNA expression patterns. This molecular compendium, fully accessible via a searchable web-browser interface, serves as a reliable reference of the expressed tissue and organelle proteomes of a leading model mammal. ... [Information of the supplier]
Online Mendelian Inheritance in Animals (OMIA) is a database of genes, inherited disorders and traits in more than 135 animal species (other than human and mouse) authored by Professor Frank Nicholas of the University of Sydney, Australia, with help from many people over the years. The database contains textual information and references, as well as links to relevant PubMed and Gene records at the NCBI. ... [Information of the supplier]
Protein phosphorylation is a post-translational modification that regulates an astonishing number of critical biological processes in multicellular organisms. Cellular protein phosphorylation is an enormously complex dynamic system: over 510 distinct protein kinases and 100 phosphoprotein phosphatases are encoded in the human genome, and upwards of 40% of cellular proteins may be phosphorylated during some stage of growth and differentiation. Many proteins are multiply phosphorylated on scores of sites, making it likely that there are minimally 100,000 distinct phosphorylation sites in the mammalian proteome. It is the intention of the scientists who are designing and implementing PhosphoSite to provide an accurate and comprehensive source of information about mammalian protein phosphorylation sites. Our goal is to identify and organize information about all in vivo phosphorylation sites in human and mouse proteomes and to provide information and resources that will facilitate phosphorylation research. PhosphoSite is a curated, sequence-oriented protein database dedicated to in vivo phosphorylation sites. Information in PhosphoSite version 1.0 includes: (a) The phosphorylated residue and its surrounding sequence. We consider this information to be the central, organizing feature of PhosphoSite. (b) Orthologous sites in other species; this should assist investigators in determining if a phosphorylation site in species A might also be phosphorylated in species B. (c) The location within domains and motifs; this should assist investigators in inferring possible biological functions of phosphorylation sites. (d) Links to other online resources including the Alliance for Cell Signaling, the Protein Kinase Resource, and Scansite. Scansite predicts likely sites for protein phosphorylation by particular kinases and likely sites for interaction with other signaling proteins. This information, based upon vitro data, will be highly complimentary to that provided by PhosphoSite. (e) Literature references which demonstrate the in vivo nature and significance of the phosphorylation site. (...) Curated information will come from literature reports as well as from high-throughput phosphosite discovery programs. Information extracted from the public domain will be freely available for educational users. Proprietary information from phosphorylation site discovery programs may be available on a subscription basis. Corporations will need to pay a reasonable yearly fee to legally access PhosphoSite. ... [Information of the supplier, modified]
This collection features approximately 4500 full page plates and other significant illustrations of human anatomy selected from the Jason A. Hannah and Academy of Medicine collections in the history of medicine at the Thomas Fisher Rare Book Library, University of Toronto. Each illustration has been fully indexed using medical subject headings (MeSH), and techniques of illustration, artists, and engravers have been identified whenever possible. There are ninety-five individual titles represented, ranging in date from 1522 to 1867. ... [Information of the supplier]
The ‘MorphoBrowser’ database and interface is a 3D visualisation and searching tool for mammalian teeth, accessible over the web. It allows the user to ‘browse’ through the diverse range of tooth morphologies found in mammals, both extinct and extant. While browsing, the three-dimensional shape of the teeth can be viewed from any direction by rotating and scaling the tooth. ... [Information of the supplier]
This educational Web site, designed to serve as a resource for students, teachers, and the general public interested in the biology and identification of mammals in North America, was developed by the External Affairs and Public Programs Division of the Smithsonian Institution's National Museum of Natural History. The resources we make available are derived from the Museum's unparalleled natural history collections, its scientific research, permanent and special exhibits, libraries, and through collaborations with other organizations and individuals with special resources to complement the site. This Web site includes detailed descriptions, images, and distribution ranges for more than 400 mammals native to the North American continent. The primary resources for the site have been based in the continental United States, but as the opportunity occurs, the site will be expanded to complete the species found in Canada and Mexico. ... [Information of the supplier]
This site, which is under development, provides electronic access to field notebooks archived in the Museum of Vertebrate Zoology collections. The goals of this project are to capture metadata on notebook volumes and sections, and to scan and reference pages for online browsing and querying. Current grant support provides funding to focus on digitization of a subset of historical materials pertaining to major early (1900-1950) faunal expeditions in California. Some of this material is unknown to the scientific community, and its usefulness will grow as it is made available. The majority of our field notes are associated with specimens deposited in the MVZ collections. Ultimately, our goal is to digitally link information from field notes, specimens, photographs, maps, and other materials (e.g., sound recordings) to maximize access for scientific researchers, conservation and management agencies, non-governmental organizations, historians, and other users. ... [Information of the supplier]
