The p53 tumor suppressor gene was initially identified as being essential for the DNA damage checkpoint, but it was subsequently found to have a broader function after cellular stress, such as oncogene activation or hypoxia. The p53 protein functions as a tetrameric transcription factor found at very low levels in normal unstressed cells. After stress, different pathways lead to post-translational modification of the protein and its stabilization. p53 database contains 16,000+ entries corresponding to TP53 mutations found in tumors, normal skin, and noncancerous diseases such as rheumatoid arthritis. The database also includes germline mutations found in Li-Fraumeni syndrome (LFS) and LFS-like syndrome. ... [Information of the supplier, modified]
The HIV databases contain data on HIV genetic sequences, immunological epitopes, drug resistance-associated mutations, and vaccine trials. The website also gives access to a large number of tools that can be used to analyze these data. This project is funded by the Division of AIDS of the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health (NIH). ... [Information of the supplier]
ChemMine is a compound mining database that facilitates drug and agrochemical discovery and chemical genomics screens. Its web service is divided into three major functional components: (1) Compound Database, comprising Annotation Search and Structure Search; (2) Cheminformatics Workbench; and (3) Screening Database. A detailed tutorial for using ChemMine's online services is available on the ReadMe page. ... [Information of the supplier, modified]
The Genetic Association Database is an archive of human genetic association studies of complex diseases and disorders. The goal of this database is to allow the user to rapidly identify medically relevant polymorphism from the large volume of polymorphism and mutational data, in the context of standardized nomenclature. ... [Information of the supplier]
The Environmental Data Explorer is the authoritative source for data sets used by UNEP and its partners in the Global Environment Outlook (GEO) report and other integrated environment assessments. Its online database holds more than 500 different variables, as national, subregional, regional and global statistics or as geospatial data sets (maps), covering themes like Freshwater, Population, Forests, Emissions, Climate, Disasters, Health and GDP. Display them on-the-fly as maps, graphs, data tables or download the data in different formats. ... [Information of the supplier]
The HCV database group strives to present HCV-associated genetic and immunologic data in a userfriendly way, by providing access to the central database via web-accessible search interfaces and supplying a number of analysis tools. (...) The HCV search interface allows you to find and download sequences on the basis of a number of criteria. (...) You can either download all sequences (as nucleotides or amino acid sequences) that meet your criteria, or you can limit your set to a specific gene or region by selecting that genomic region on the search interface. (...) ... [Information of the supplier, modified]
Influenza Virus Resource presents data obtained from the NIAID Influenza Genome Sequencing Project as well as from GenBank, combined with tools for flu sequence analysis and annotation. In addition, it provides links to other resources that contain flu sequences, publications and general information about flu viruses. [Information of the supplier]
The internet Primate Aging Database (iPAD) is a multi-centered, relational database of biological variables in aging, captive nonhuman primates. Through joint initiative of the National Institute on Aging (intramural and extramural programs), National Center for Research Resources (NCRR), and the National Primate Research Center at the University of Wisconsin-Madison (WNPRC), we have organized a database to study biomarkers of aging in nonhuman primates. iPAD also provides an invaluable veterinary and clinical resource, and can generate normative data for numbers of animals across research settings. iPAD now contains over 400,000 data points for body weight, blood chemistry and hematology, for healthy, non-experimental subjects across time. ... [Information of the supplier]
T1DBase is a public website and database that supports the type 1 diabetes (T1D) research community. It is being created by a joint effort between the Institute for Systems Biology, Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory and the Juvenile Diabetes Research Foundation International. T1DBase collects information from public sources and from collaborating laboatories, integrates this information, and presents it in a form that is useful for T1D researchers. The current data scope includes annotated genomic sequences for suspected T1D susceptibility regions; microarray data; functional annotation of genes active in beta cells; and "global"datasets, generally from the literature, that are useful for systems biology studies. ... [Information of the supplier, modified]
This collection features approximately 4500 full page plates and other significant illustrations of human anatomy selected from the Jason A. Hannah and Academy of Medicine collections in the history of medicine at the Thomas Fisher Rare Book Library, University of Toronto. Each illustration has been fully indexed using medical subject headings (MeSH), and techniques of illustration, artists, and engravers have been identified whenever possible. There are ninety-five individual titles represented, ranging in date from 1522 to 1867. ... [Information of the supplier]
