M phase, also called as cell division, is the most crucial and fundamental affair of the eukaryotic cell cycle. After the chromosomes have been replicated during the S phase, the sister chromatids are separated and distributed into two daughter cells equally and faithfully. Also, each daughter cell receives the almost average and necessary intracellular constituents and organelles from the mother cell. Generally, cell division consists of six stages, including prophase, prometaphase, metaphase, anaphase, telophase and cytokinesis. And the first five stages constituent mitosis. During mitosis, numerous proteins organize protein super-complexes at the three distinct regions of centrosome, kinetochore/centromere and cleavage furrow/midbody. Although many proteins have been identified to be localized on centrosome, kinetochore and/or midbody, an integrated resource on this area still remains not to be available. In this work, we have collected all proteins identified to be localized on kinetochore, centrosome, and/or midbody from two fungi (S. cerevisiae and S. pombe) and five animals, including C. elegans, D. melanogaster, X. laevis, M. musculus and H. sapiens. From the related literature of PubMed, numerous proteins have been manually curated to be localized on at least one of the sub-cellular localizations of kinetochore, centrosome and midbody. And to promise the quality of data, based on the rationale of "Seeing is believing", these proteins have been unambiguously observed under fluorescent microscope as directly supportive evidences. Then an integrated and searchable database MiCroKit - Midbody, Centrosome and Kinetochore has been established. The MiCroKit database is the first integrative resource to pin point most of identified components and related scientific information of midbody, centrosome and kinetochore. The version 1.0 of MiCroKit database was set up on Nov. 2nd, 2005, containing 1,065 unique proteins. The MiCroKit version 2.0 was released on Jun. 5th, 2006, with 1,120 entries. Currently, the MiCroKit 3.0 database was updated on July 9, 2009, containing 1,489 unique protein entries. ... [Information of the supplier, modified]
The Jena Library of Biological Macromolecules (JenaLib) is aimed at a better dissemination of information on three-dimensional biopolymer structures with an emphasis on visualization and analysis. It provides access to all structure entries deposited at the Protein Data Bank (PDB) or at the Nucleic Acid Database (NDB). In addition, basic information on the architecture of biopolymer structures is available. The JenaLib intends to fulfill both scientific and educational needs. ... [Information of the supplier]
BEKIS is an online database, which provides ready access to information about national and international institutions and activities in the area of bioethics research. Users can find information about: research institutions, research groups, research projects and events. [Information of the supplier]
BELIT is an integrated bibliographic database developed by the German Reference Centre for Ethics in the Life Sciences (DRZE, Bonn) and operated in co-operation with the Information and Documentation Centre for Ethics in Medicine (IDEM, Goettingen), the Interdepartmental Centre for Ethics in the Sciences and Humanities (IZEW, Tuebingen), the Library and Information Services of the Kennedy Institute of Ethics (KIE, Washington, DC) and the Centre de documentation en éthique des sciences de la vie et de la santé, INSERM/CCNE (CDEI, Paris). BELIT provides access to about 320.000 records from the integrated German, American and French databases. It is an extensive bibliographic directory of literature in the area of bioethics unique world wide, containing references to monographs, grey literature, legal documents, journal articles, newspaper articles and book contributions. ... [Information of the supplier]
The EMBL Nucleotide Sequence Database (also known as EMBL-Bank) constitutes Europe's primary nucleotide sequence resource. Main sources for DNA and RNA sequences are direct submissions from individual researchers, genome sequencing projects and patent applications. The database is produced in an international collaboration with GenBank (USA) and the DNA Database of Japan (DDBJ). Each of the three groups collects a portion of the total sequence data reported worldwide, and all new and updated database entries are exchanged between the groups on a daily basis. The current database release (Release 87, June 2006), with according Release notes and user manual are available from the EBI servers. ... [Information of the supplier]
The Entrez Nucleotides database is a collection of sequences from several sources, including GenBank, RefSeq, and PDB. The number of bases in these databases continues to grow at an exponential rate. As of April 2006, there are over 130 billion bases in GenBank and RefSeq alone. [Information of the supplier]
The observatory is a system of databases with worldwide coverage in bioethics and other areas of applied ethics in science and technology such as environmental ethics, science ethics, and technology ethics. [Information of the supplier]
The human genome seems to encode for not more than 30,000 to 40,000 proteins. A major challenge is to understand how posttranslational events, such as glycosylation, affect the activities and functions of these proteins in health and disease. The importance of protein glycosylation is becoming widely realized through studies on protein folding, protein localization and trafficking, protein solubility, biological half-life as well as studies on cell-cell interactions. The progressing Glycomics projects will dramatically accelerate the understanding of the roles of carbohydrates in cell communication and lead to novel therapeutic approaches for treatment of human disease. The MIT's magazine of innovation (January 21 2003) has identified Glycomics as one of the top ten technologies that will change the future. To support the upcoming Glycomics projects we [German Cancer Research Center (DKFZ), Heidelberg] focus our research activities on the development of bioinformatic tools and databases for glycobiology. ... [Information of the supplier]
A grand challenge in the post-genomic era is a complete computer representation of the cell, the organism, and the biosphere, which will enable computational prediction of higher-level complexity of cellular processes and organism behaviors from genomic and molecular information. Towards this end we have been developing a bioinformatics resource named KEGG as part of the research projects of the Kanehisa Laboratories in the Bioinformatics Center of Kyoto University and the Human Genome Center of the University of Tokyo. (...) KEGG is a suite of databases and associated software, integrating our current knowledge on the function and utility of biological systems (PATHWAY and BRITE databases), the information about the universe of genes and proteins (GENES database), and the information about the universe of chemical compounds and reactions (LIGAND database). ... [Information of the supplier]
The Molecular Modeling Database (MMDB) contains 3D macromolecular structures, including proteins and polynucleotides. MMDB contains over 28,000 structures and is linked to the rest of the NCBI databases, including sequences, bibliographic citations, taxonomic classifications, and sequence and structure neighbors. [Information of the supplier]
